4.7 Article

Soluble Carrier Transporters and Mitochondria in the Immunometabolic Regulation of Macrophages

期刊

ANTIOXIDANTS & REDOX SIGNALING
卷 36, 期 13, 页码 906-919

出版社

MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2021.0181

关键词

macrophages; SLCs; metabolism; mitochondria; immunometabolism; inflammation

资金

  1. Sao Paulo Research Foundation-FAPESP [2013/07607-8, 2015/15626-8, 2019/25973-8, 2019/19435-3]
  2. CNPq
  3. NIH/NIDDK K01 Career Development Award [K01 DK114162-01A1]
  4. CAPES

向作者/读者索取更多资源

Studies have shown that solute carriers play a significant role in regulating macrophage metabolism, affecting mitochondrial activity and intracellular processes, which ultimately impact the functional status of macrophages.
Significance: Immunometabolic regulation of macrophages is a growing area of research across many fields. Here, we review the contribution of solute carriers (SLCs) in regulating macrophage metabolism. We also highlight key mechanisms that regulate SLC function, their effects on mitochondrial activity, and how these intracellular activities contribute to macrophage fitness in health and disease.Recent Advances: SLCs serve as a major drug absorption pathway and represent a novel category of therapeutic drug targets. SLC dynamics affect cellular nutritional sensors, such as AMP-activated protein kinase and mammalian target of rapamycin, and consequently alter the cellular metabolism and mitochondrial dynamics within macrophages to adapt to a new functional phenotype.Critical Issues: SLC function affects macrophage phenotype, but their mechanisms of action and how their functions contribute to host health remain incompletely defined.Future Directions: Few studies focus on the impact of solute transporters on macrophage function. Identifying which SLCs are present in macrophages and determining their functional roles may reveal novel therapeutic targets with which to treat metabolic and inflammatory diseases.

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