期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 65, 期 8, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00486-21
关键词
Enterobacterales; MBL; antibiotic resistance; antimicrobial combinations; aztreonam-avibactam; beta-lactamases; carbapenemases; susceptibility testing
资金
- Centers for Disease Control and Prevention's internal funding
Aztreonam-avibactam, a drug combination currently in phase 3 clinical trials, has shown potent in vitro activity against metallo-beta-lactamase (MBL)-producing Enterobacterales.
Aztreonam-avibactam is a drug combination pending phase 3 clinical trials and is suggested for treatment of severe infections caused by metallo-beta-lactamase (MBL)-producing Enterobacterales by combining ceftazidime-avibactam and aztreonam. Beginning in 2019, four Antibiotic Resistance Laboratory Network regional laboratories offered aztreonam-avibactam susceptibility testing by broth microdilution. For 64 clinical isolates tested, the MIC50 and MIC90 values of aztreonam-avibactam were 0.5/4 mu g/ml and 8/4 mu g/ml, respectively. Aztreonam-avibactam displayed potent in vitro activity against the MBL-producing Enterobacterales tested.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据