期刊
ANTI-CANCER DRUGS
卷 33, 期 1, 页码 E198-E206出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CAD.0000000000001185
关键词
aerobic glycolysis; apoptosis; fructose-1; 6-bisphosphatase 2; growth; pyruvate kinase isozyme type M2
资金
- Guizhou Medical university start-up fund for doctoral talent [J-[2020]043]
- Guizhou education department yoGuizhou medical university 2020 academic new seedling cultivation and innovation exploration special plan [19NSP010]
- Guiyang Municipal Science and Technology Bureau [[2018] 1-37]
- uth science and technology talent growth program [[2021]185]
Growing evidence supports the important role of aerobic glycolysis in cervical cancer. This study reveals that FBP2 plays a role in cervical cancer progression by inhibiting aerobic glycolysis through inducing PKM2 ubiquitination.
Growing evidence has shown that aerobic glycolysis, as a hallmark of cancer cells, plays a crucial role in cervical cancer. The aim of the study is to uncover whether fructose-1,6-bisphosphatase 2 (FBP2) is involved in cervical cancer progression via the aerobic glycolysis pathway. FBP2 levels were determined by quantitative PCR (qPCR) and western blotting. Cell growth viability and apoptosis were tested by cell counting kit-8 (CCK-8) and flow cytometry assays. Immunoprecipitation assay was applied for the detection of the FBP2 effect on pyruvate kinase isozyme type M2 (PKM2) ubiquitination. FBP2 level was decreased in cervical cancer, which is closely linked to shorter overall survival. FBP2 decreased cell growth and aerobic glycolysis and increased cell apoptosis, as well as decreased PKM2 expression and increased its ubiquitination level. The above-mentioned roles of FBP2 were weakened followed by PKM2 overexpression. FBP2 inhibited cervical cancer cell growth via inhibiting aerobic glycolysis by inducing PKM2 ubiquitination.
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