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Loss of stretch-activated channels, PIEZOs, accelerates non-small cell lung cancer progression and cell migration
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Amphipathic molecules modulate PIEZO1 activity
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Stimulation of Piezo1 by mechanical signals promotes bone anabolism
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BRITISH JOURNAL OF PHARMACOLOGY (2019)
A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels
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Dominique Douguet et al.
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Expression and distribution of PIEZO1 in the mouse urinary tract
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Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation
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BRITISH JOURNAL OF PHARMACOLOGY (2018)
Common PIEZO1 Allele in African Populations Causes RBCDehydration and Attenuates Plasmodium Infection
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PIEZO1 functions as a potential oncogene by promoting cell proliferation and migration in gastric carcinogenesis
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A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel
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A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release
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The increased expression of Piezo1 and Piezo2 ion channels in human and mouse bladder carcinoma
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PIEZO2 mediates injury-induced tactile pain in mice and humans
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Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes
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Piezo's membrane footprint and its contribution to mechanosensitivity
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Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
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Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity
Christiane Wetzel et al.
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Piezos thrive under pressure: mechanically activated ion channels in health and disease
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Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance
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Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix
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CELL REPORTS (2017)
Structure-based membrane dome mechanism for Piezo mechanosensitivity
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ELIFE (2017)
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Piezo1 regulates mechanotransductive release of ATP from human RBCs
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Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides
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Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia
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Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis
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Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line
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Piezo1 links mechanical forces to red blood cell volume
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Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension
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ELIFE (2015)
Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides
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The force-from-lipid (FFL) principle of mechanosensitivity, at large and in elements
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Ionic Selectivity and Permeation Properties of Human PIEZO1 Channels
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Mutations in PIEZO2 Cause Gordon Syndrome, Marden-Walker Syndrome, and Distal Arthrogryposis Type 5
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Piezo1 Is as a Novel Trefoil Factor Family 1 Binding Protein that Promotes Gastric Cancer Cell Mobility In Vitro
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Functional Role for Piezo1 in Stretch-evoked Ca2+ Influx and ATP Release in Urothelial Cell Cultures
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Piezo2 is required for Merkel-cell mechanotransduction
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Piezol integration of vascular architecture with physiological force
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Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl
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Piezo1, a mechanically activated ion channel, is required for vascular development in mice
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Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch
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Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis
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Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis
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Piezo proteins are pore-forming subunits of mechanically activated channels
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NATURE (2012)
Loss of the Integrin-Activating Transmembrane Protein Fam38A (Piezo1) Promotes a Switch to a Reduced Integrin-Dependent Mode of Cell Migration
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Differential effects of lipids and lyso-lipids on the mechanosensitivity of the mechanosensitive channels MscL and MscS
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PHYSIOLOGICAL REVIEWS (2010)
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SCIENCE (2010)
Mechanosensor channels in mammalian somatosensory neurons
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Lysophospholipids open the two-pore domain mechano-gated K+ channels TREK-1 and TRAAK
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