Antimicrobial Activity of Metals and Metalloids

Competition shapes evolution. Toxic metals and metalloids have exerted selective pressure on life since the rise of the first organisms on the Earth, which has led to the evolution and acquisition of resistance mechanisms against them, as well as mechanisms to weaponize them. Microorganisms exploit antimicrobial metals and metalloids to gain competitive advantage over other members of microbial communities. This exerts a strong selective pressure that drives evolution of resistance. This review describes, with a focus on arsenic and copper, how microorganisms exploit metals and metalloids for predation and how metal- and metalloid-dependent predation may have been a driving force for evolution of microbial resistance against metals and metalloids.

Automated summary

Competition drives evolution, with toxic metals and metalloids exerting selective pressure on life, leading to the evolution of resistance mechanisms in microorganisms. Microorganisms exploit antimicrobial metals to gain competitive advantage, which in turn drives the evolution of resistance mechanisms against these metals and metalloids.