4.5 Article

Combination of novel molecular targeted agent plus R-CHOP-based regimen versus R-CHOP alone in previously untreated diffuse large B-cell lymphoma (DLBCL) patients: a systematic review and meta-analysis.

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Subcutaneous Rituximab-MiniCHOP Compared With Subcutaneous Rituximab-MiniCHOP Plus Lenalidomide in Diffuse Large B-Cell Lymphoma for Patients Age 80 Years or Older

Lucie Oberic et al.

Summary: The prognosis of elderly patients with DLBCL is worse than that of young patients. An attenuated dose of chemotherapy and addition of lenalidomide does not significantly improve overall survival compared to standard treatment.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

Addition of Lenalidomide to R-CHOP Improves Outcomes in Newly Diagnosed Diffuse Large B-Cell Lymphoma in a Randomized Phase II US Intergroup Study ECOG-ACRIN E1412

Grzegorz S. Nowakowski et al.

Summary: The addition of lenalidomide to R-CHOP (R2CHOP) in newly diagnosed DLBCL, particularly in the ABC-DLBCL subtype, showed improved outcomes including better progression-free survival and overall survival rates. This study suggests that R2CHOP may be an effective treatment option for patients with DLBCL, especially those with the ABC-DLBCL subtype.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

ROBUST: A Phase III Study of Lenalidomide Plus R-CHOP Versus Placebo Plus R-CHOP in Previously Untreated Patients With ABC-Type Diffuse Large B-Cell Lymphoma

Grzegorz S. Nowakowski et al.

Summary: The ROBUST study aimed to compare the efficacy of lenalidomide plus R-CHOP with placebo/R-CHOP in previously untreated ABC-type DLBCL. While the primary end point of progression-free survival (PFS) was not met in all patients, there were trends favoring R2-CHOP over placebo/R-CHOP in patients with higher-risk disease. The safety profile of R2-CHOP was consistent with individual treatments with no new safety signals.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Review Oncology

R-CHOP compared to R-CHOP plus X for newly diagnosed diffuse large B-cell lymphoma: a systematic review and meta-analysis

Oren Pasvolsky et al.

Summary: Adding another drug to R-CHOP as frontline treatment for DLBCL did not significantly improve overall survival, but did show significant advantages in disease control. The addition of lenalidomide to R-CHOP may have the most notable impact on treatment efficacy, although it also comes with increased risk of adverse events. Further research may help identify subgroups that could benefit the most from augmenting standard R-CHOP.

ACTA ONCOLOGICA (2021)

Article Medicine, General & Internal

Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma

R. Schmitz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Biochemistry & Molecular Biology

Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma

Wyndham H. Wilson et al.

NATURE MEDICINE (2015)

Article Hematology

The Genetic Landscape of Diffuse Large B-Cell Lymphoma

Laura Pasqualucci et al.

SEMINARS IN HEMATOLOGY (2015)

Article Medicine, General & Internal

Stromal Gene Signatures in Large-B-Cell Lymphomas

G. Lenz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Medicine, General & Internal

CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma.

B Coiffier et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)