期刊
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
卷 127, 期 5, 页码 553-+出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.anai.2021.06.012
关键词
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资金
- US National Institutes of Health (NIH) [R01 HL095606, R01 HL114396, R21 ES021318, R21HD080359, R01 ES030302]
- NIH [P30 ES023515, UL1 TR001363]
- [R01 HL132338]
- [T32HD049311]
Associations between prenatal PUFA intake and childhood asthma are modified by prenatal active maternal asthma or child sex. Lower maternal n-3 PUFA intake is significantly associated with risk of childhood asthma, especially among children of mothers with active asthma and low n-3 PUFA intake.
Background: Studies evaluating effects of prenatal polyunsaturated fatty acid (PUFA) intake on childhood asthma reveal mixed results. Inconsistencies may result from not accounting for important modifying factors such as maternal asthma or child sex. Objective: To evaluate whether associations between prenatal PUFA intake and childhood asthma are modified by prenatal active maternal asthma or child sex in 412 mother-child dyads. Methods: Energy-adjusted prenatal dietary and supplement intakes of omega-3 (n-3) and omega-6 (n-6) PUFAs were estimated using the Block98 Food Frequency Questionnaire, administered during pregnancy. Mothers reported asthma in children followed prospectively to 4.0 plus or minus 1.7 years. Generalized additive models with smooth terms for PUFA (n-3, n-6, n-6/n-3 ratio) effects were used to investigate associations between PUFAs and child asthma, without prespecifying the form of these relationships, including effect modification by active maternal asthma or child sex. Results: Among mothers (40% Black, 31% Hispanic), 22% had active asthma in pregnancy; 17.5% of children developed asthma. Lower maternal n-3 PUFA intake was significantly associated with risk of childhood asthma (P = .03), in particular among children of mothers with active asthma and low n-3 PUFA intake (P = .01). This inverse association was more apparent in girls (P = .01) compared with boys (P = .30), regardless of maternal asthma status. For n-6 PUFA and the n-6/n-3 ratio, there was a lower risk of childhood asthma in the midrange of intake and increased risk at higher intake (n-6 PUFA P = .10, n-6/n-3 ratio P = .13). Conclusion: Consideration of factors that modify effects of prenatal PUFA intake on childhood asthma has implications for designing intervention strategies tailored to impact those at greatest risk. (C) 2021 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
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