4.5 Article

Comparison of major histocompatibility complex-B variability in Sri Lankan indigenous chickens with five global chicken populations using MHC-B SNP panel

期刊

ANIMAL GENETICS
卷 52, 期 6, 页码 824-833

出版社

WILEY
DOI: 10.1111/age.13137

关键词

crossbreed; disease resistance; haplotype diversity; major histocompatibility complex-B; Sri Lankan indigenous chicken

资金

  1. National Research Foundation, Republic of Korea [MHC-2019R1F1A1061670]
  2. National Research Foundation of Korea [2019R1F1A1061670] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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This study investigated the MHC-B haplotypes diversity of Sri Lankan indigenous chickens using 90 SNPs, identifying a total of 48 haplotypes, including 37 novel haplotypes and 11 standard haplotypes. Comparison with global populations showed sharing of 23 standard haplotypes with common origins.
In the present study, we investigated the major histocompatibility complex (MHC)-B haplotypes diversity of Sri Lankan indigenous chickens from three different geographical sites consisting of highly mixed populations using 90 SNPs in the MHC-B region. A total of 48 haplotypes were identified. Those included 37 novel haplotypes and 11 previously identified 'standard' haplotypes. The MHC-linked marker, LEI0258, had 23 alleles showing less diversity than defined by MHC-B SNP haplotypes. Among those identified haplotypes, five standard haplotypes-BSNP-O02, BSNP-M01, BSNP-A04, BSNP-K03, BSNP-T04-were most commonly observed, suggesting past introgression of imported breeds. Comparison of the MHC-B haplotypes of Sri Lankan and four other global populations with previously defined haplotypes indicated the sharing of 23 standard haplotypes with common origins. Novel haplotypes are population-specific and not shared among the geographical boundaries. Backyard indigenous chickens are unselected, highly crossbred, and generally thrive under dynamic environmental conditions. Hence free-range production systems may be responsible for maintaining high diversity in the MHC-B region with novel haplotypes.

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