期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 47, 页码 24854-24858出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202110641
关键词
carbenoids; chemoselectivity; homologation; isothiocyanates; thietanes
资金
- University of Vienna
- University of Turin
- Universita degli Studi di Torino within the CRUI-CARE Agreement
The study reports a formal CH2-CH2 homologation conducted with C1 carbenoids on a carbon electrophile for the obtainment of a four-membered cycle, resulting in the assembling of a rare imino-thietane cluster. The double homologation protocol demonstrates genuine chemocontrol and is accomplished directly on a carbon electrophile without the need for heteroatom-centered manifolds.
A formal CH2-CH2 homologation conducted with C1 carbenoids on a carbon electrophile for the obtainment of a four-membered cycle is reported. The logic proposes the consecutive delivery of two single nucleophilic CH2 units to an isothiocyanate-as competent electrophilic partner-resulting in the assembling of a rare imino-thietane cluster. The single synthetic operation procedure documents genuine chemocontrol, as indicated by the tolerance to various reactive elements decorating the starting materials. Significantly, the double homologation protocol is accomplished directly on a carbon electrophile, thus not requiring the installation of heteroatom-centered manifolds (e.g. boron).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据