期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 47, 页码 25151-25160出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202110450
关键词
allyl ligands; C-C coupling; cross coupling; homogeneous catalysis; palladium
资金
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence [EXC-2033-390677874-RESOLV, SFB TRR88]
- BMBF
- state of NRW (Center of Solvation Science ZEMOS)
- Fonds der chemischen Industrie FCI
- CSC
- Projekt DEAL
Halogen-bridged methylnaphthyl (MeNAP) palladium dimers, presented as versatile Pd precursors, demonstrate excellent catalytic performance by in situ conversion into well-defined monoligated complexes. They show benchmark activities in challenging reactions, enable record-setting yields, and can achieve previously elusive cross-couplings.
Halogen-bridged methylnaphthyl (MeNAP) palladium dimers are presented as multipurpose Pd-precursors, ideally suited for catalytic method development and preparative organic synthesis. By simply mixing with phosphine or carbene ligands, they are in situ converted into well-defined monoligated complexes. Their catalytic performance was benchmarked against state-of-the-art systems in challenging Buchwald-Hartwig, Heck, Suzuki and Negishi couplings, and ketone arylations. Their use enabled record-setting activities, beyond those achievable by optimization of the ligand alone. The MeNAP catalysts permit syntheses of tetra-ortho-substituted arenes and bulky anilines in near-quantitative yields at room temperature, allow mono-arylations of small ketones, and enable so far elusive cross-couplings of secondary alkyl boronic acids with aryl chlorides.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据