期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 61, 期 1, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202108364
关键词
coordination polymers; foldamers; metal-peptide frameworks
资金
- National Research Foundation of Korea (NRF) - Korean government (Ministry of Science and ICT) [NRF-2019R1A6A1A10073887, 2020R1C1C1011134, 2018R1A5A1025208]
- National Research Foundation of Korea (NRF) - Korean government (Ministry of Education) [NRF-2019R1A6A1A10073887, 2020R1C1C1011134, 2018R1A5A1025208]
- National Research Foundation of Korea [2020R1C1C1011134] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study presents the first metal-coordination-mediated assembly of beta-peptide foldamers with 12-helical folding propensity, resulting in unique entangled metal-peptide frameworks. The formation of network structures is accompanied by notable conformational distortions of the foldamer ligands. This work is expected to be an important benchmark for further structural evolution and mechanistic investigation in the field of metal-peptide frameworks.
Metal-coordinated frameworks derived from small peptidic ligands have received much attention thanks to peptides' vast structural and functional diversity. Various peptides with partial conformational preferences have been used to build metal-peptide frameworks, however, the use of conformationally constrained beta-peptide foldamers has not been explored yet. Herein we report the first metal-coordination-mediated assembly of beta-peptide foldamers with 12-helical folding propensity. The coordination of Ag+ to the terminal pyridyl moieties afforded a set of metal-peptide frameworks with unique entangled topologies. Interestingly, formation of the network structures was accompanied by notable conformational distortions of the foldamer ligands. As the first demonstration of new metal-peptide frameworks built from modular beta-peptide foldamers, we anticipate that this work will be an important benchmark for further structural evolution and mechanistic investigation.
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