4.8 Article

DNA-Based Synthetic Growth Factor Surrogates with Fine-Tuned Agonism**

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Scan and Unlock: A Programmable DNA Molecular Automaton for Cell-Selective Activation of Ligand-Based Signaling

Jinghui Zhang et al.

Summary: Selective modulation of ligand-receptor interaction is crucial in targeted therapy. The SUDA system uses embedded DNA-based chemical reaction networks to scan and evaluate molecular profiles of cell-surface proteins, achieving cell-specific signal modulation by quickly unlocking the protein-ligand in proximity to the target cell-surface. The versatility of the SUDA strategy is shown through engineering TNF alpha to induce programmed cell death of target cell subpopulations.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Multidisciplinary

Nongenetic control of receptor signaling dynamics using a DNA-based optochemical tool

Ryosuke Ueki et al.

Summary: The optochemical tool based on DNA can control the dynamics of growth factor signaling, providing the opportunity to study the relationship between signal dynamics and biological outcomes, as well as manipulate cellular functions and the fate of living cells.

CHEMICAL COMMUNICATIONS (2021)

Article Medicine, Research & Experimental

Binding and Structural Properties of DNA Aptamers with VEGF-A-Mimic Activity

Toru Yoshitomi et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Article Chemistry, Multidisciplinary

Aptamers with Tunable Affinity Enable Single-Molecule Tracking and Localization of Membrane Receptors on Living Cancer Cells

Pietro Delcanale et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Bispecific Aptamer Induced Artificial Protein-Pairing: A Strategy for Selective Inhibition of Receptor Function

Liping Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Article Chemistry, Multidisciplinary

Logic-Gate-Actuated DNA-Controlled Receptor Assembly for the Programmable Modulation of Cellular Signal Transduction

Shan Chen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Chemistry, Multidisciplinary

DNA aptamer assemblies as fibroblast growth factor mimics and their application in stem cell culture

Ryosuke Ueki et al.

CHEMICAL COMMUNICATIONS (2019)

Article Chemistry, Multidisciplinary

Light-Induced Activation of c-Met Signalling by Photocontrolled DNA Assembly

Shan Chen et al.

CHEMISTRY-A EUROPEAN JOURNAL (2018)

Article Biochemistry & Molecular Biology

MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner

Wenyu Miao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Biotechnology & Applied Microbiology

Aptamers as targeted therapeutics: current potential and challenges

Jiehua Zhou et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Article Chemistry, Multidisciplinary

Nongenetic Reprogramming of the Ligand Specificity of Growth Factor Receptors by Bispecific DNA Aptamers

Ryosuke Ueki et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Biochemistry & Molecular Biology

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling

Chia Chi M. Ho et al.

Article Chemistry, Multidisciplinary

Oligonucleotide-Based Mimetics of Hepatocyte Growth Factor

Ryosuke Ueki et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Article Biochemistry & Molecular Biology

Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands

Ignacio Moraga et al.

Article Biochemistry & Molecular Biology

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency

Ignacio Moraga et al.

SCIENCE SIGNALING (2015)

Article Multidisciplinary Sciences

Artificial human Met agonists based on macrocycle scaffolds

Kenichiro Ito et al.

NATURE COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

DNA Aptamer Assembly as a Vascular Endothelial Growth Factor Receptor Agonist

Vidhya Ramaswamy et al.

NUCLEIC ACID THERAPEUTICS (2015)

Article Biochemistry & Molecular Biology

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency

Ignacio Moraga et al.

SCIENCE SIGNALING (2015)

Article Chemistry, Multidisciplinary

A DNA aptamer to c-Met inhibits cancer cell migration

R. Ueki et al.

CHEMICAL COMMUNICATIONS (2014)

Review Biochemistry & Molecular Biology

Understanding cytokine and growth factor receptor activation mechanisms

Mariya Atanasova et al.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Orientation-specific signalling by thrombopoietin receptor dimers

Judith Staerk et al.

EMBO JOURNAL (2011)

Review Cell Biology

Structural insights into Met receptor activation

Hartmut H. Niemann

EUROPEAN JOURNAL OF CELL BIOLOGY (2011)

Review Pharmacology & Pharmacy

Ligand-based receptor tyrosine kinase partial agonists: new paradigm for cancer drug discovery?

David J. Riese

EXPERT OPINION ON DRUG DISCOVERY (2011)

Article Biochemistry & Molecular Biology

Cell Signaling by Receptor Tyrosine Kinases

Mark A. Lemmon et al.

Review Biotechnology & Applied Microbiology

Aptamers as therapeutics

Anthony D. Keefe et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Review Cell Biology

MET signalling: principles and functions in development, organ regeneration and cancer

Livio Trusolino et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Article Multidisciplinary Sciences

Structural basis for agonism and antagonism of hepatocyte growth factor

W. David Tolbert et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Immunology

Structural Biology of Shared Cytokine Receptors

Xinquan Wang et al.

ANNUAL REVIEW OF IMMUNOLOGY (2009)

Article Biotechnology & Applied Microbiology

Switching constant domains enhances agonist activities of antibodies to a thrombopoietin receptor

Masayuki Kai et al.

NATURE BIOTECHNOLOGY (2008)

Article Multidisciplinary Sciences

A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist

W. David Tolbert et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Dermatology

Autocrine production of biologically active hepatocyte growth factor (HGF) by injured human skin

F Nayeri et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2006)

Review Cell Biology

Met, metastasis, motility and more

C Birchmeier et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)