期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 44, 页码 23805-23811出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202109863
关键词
chemiluminescence; gold nanoparticles; photoacoustic imaging; photo-crosslinking; photothermal therapy
资金
- Training Program of the Major Research Plan of the National Natural Science Foundation of China [91959123]
- Key Research and Development Program of Social Development of Jiangsu Province [BE2018655]
- National Science Foundation of China [22077092]
- Open Project Program of the State Key Laboratory of Radiation Medicine and Protection [GZK1202017, GZK1201916]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Developing endogenous photo-activated theranostic platforms is crucial for cancer diagnosis and treatment. A chemiluminescence-triggered nanoparticle aggregation strategy was developed to activate the theranostic functions of gold nanoparticles, enhancing tumor imaging and therapy.
Developing endogenous photo-activated theranostic platforms to overcome the limitation of low tissue-penetration from external light sources is highly significant for cancer diagnosis and treatment. We report a H2O2-initiated chemiluminescence (CL)-triggered nanoparticle aggregation strategy to activate theranostic functions of gold nanoparticles (AuNPs) for effective tumor imaging and therapy. Two types of AuNPs (tAuNP & mAuNP) were designed and fabricated by conjugating 2,5-diphenyltetrazole and methacrylic acid onto the surface of AuNPs, respectively. Luminol was adsorbed onto the mAuNPs to afford self-illuminating mAuNP/Lu NPs that could produce strong CL by reaction with H2O2 in the tumor microenvironment, which triggers significant aggregation of AuNPs resulting in enhanced accumulation and retention of AuNPs for activated photoacoustic imaging and photothermal therapy of tumors. We thus believe that this approach may offer a promising tool for effective tumor treatment.
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