期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 40, 页码 21673-21678出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202106147
关键词
DNA nanotechnology; G-Quadruplex; hybridization chain reaction (HCR); photodynamic therapy; theranostic
资金
- Ministry of Education of Taiwan (Higher Education Sprout Project)
- Ministry of Science and Technology of Taiwan [106-2113-M-002-014-MY3, 106-2622-367-M-002-003-CC2, 107-2622-M-002-001-CC2, 106-2811-M-002-099, 109-2113-M-002-007-MY3, 107-2113-M-033-010-MY2]
DNA nanotechnology provides a powerful tool for developing cancer theranostics, with autonomous surface-nucleolin-guided HCR leading to the formation of Zn-II PPIX-loaded G-quadruplex polymer chains for selective imaging and cytotoxicity towards TNBC. This method offers a promising platform for targeting TNBC, which has poor prognosis and high risk of recurrence.
DNA nanotechnology provides powerful tools for developing cancer theranostics. Here we introduce the autonomous surface-nucleolin-guided HCR that leads to the polymerization of G-quadruplex polymer chains, in which the Zn-II-protoporphyrin IX is intercalated. We demonstrate that MDA-MB-231 (Triple Negative Breast Cancer cells, TNBC) with overexpressed surface nucleolin were able to induce HCR leading to the formation of the Zn-II PPIX-loaded G-quadruplex polymer chains, while the M10 epithelial breast cells served as control. The Zn-II PPIX-loaded nanowires allow the selective imaging of TNBC, and their permeation into the TNBC leads to selective cytotoxicity and guided photodynamic therapy toward the cancer cells due to structural perturbation of the membranes. The aptamer-guided HCR-generated G-quadruplex polymer chains may serve as a versatile tool to target TNBC featuring poor prognosis and high pathological risk of recurrence, thus offering a promising theranostic platform.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据