期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 34, 页码 18815-18820出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202106428
关键词
enantioselectivity; homochirality; host-guest chemistry; imines; multivalence
资金
- Chinese Thousand Youth Talents Plan
- National Natural Science Foundation of China [21532005, 21772173, 91856116]
- Natural Science Foundation of Zhejiang Province [LR18B020001]
Self-assembly of anionic tetrahedron cage in water via metal-ligand coordination shows stability and chiral selectivity, accommodating various guest molecules in aqueous media.
Self-assembly of host molecules in aqueous media via metal-ligand coordination is well developed. However, the preparation of purely covalent counterparts in water has remained a formidable task. An anionic tetrahedron cage was successfully self-assembled in a [4+4] manner by condensing a trisamine and a trisformyl in water. Even although each individual imine bond is rather labile and apt to hydrolyze in water, the tetrahedron is remarkably stable or inert due to multivalence. The tetrahedral cages, as well as its neutral counterparts dissolved in organic solvent, have homochirality, namely that their four propeller-shaped trisformyl residues adopt the same rotational conformation. The cage is able to take advantage of hydrophobic effect to accommodate a variety of guest molecules in water. When a chiral guest was recognized, the formation of one enantiomer of the cage became more favored relative to the other. As a consequence, the cage could be produced in an enantioselective manner. The tetrahedron is able to maintain its chirality after removal of the chiral guest-probably on account of the cooperative occurrence of intramolecular forces that restrict the intramolecular flipping of phenyl units in the cage framework.
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