期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 44, 页码 23569-23573出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202108076
关键词
charge-transfer interaction; metal-organic framework; organic co-crystal; photothermal therapy; self-assembly
资金
- National Natural Science Foundation of China [21820102001, 21890381, 21901033]
- China Postdoctoral Science Foundation [2019M651105]
- University of Massachusetts-Medical School
This study presents the first biological application of aqueous dispersible self-assembled organic co-crystals stabilized by metal-organic framework (MOF). By constructing a unique MOF structure, high-density ordered arrangement and close intermolecular distance were achieved, leading to superior charge transfer interaction and high photothermal conversion efficiency in aqueous solution. The platform demonstrated potential for highly effective long-wavelength light photothermal therapy in biological applications.
Organic self-assembled co-crystals have garnered considerable attention due to their facile synthesis and intriguing properties, but supramolecular interactions restrict their stability in aqueous solution, which is especially important for biological applications. Herein, we report on the first biological application of aqueous dispersible self-assembled organic co-crystals via the construction of metal-organic framework (MOF) -stabilized co-crystals. In particular, we built an electron-deficient MOF with naphthalene diimide (NDI) as the ligand and biocompatible Ca2+ as the metal nodes. An electron donor molecule, pyrene, was encapsulated to form the host-guest MOF self-assembled co-crystal. We observed that such MOF structure leads to uniquely high-density ordered arrangement and the close intermolecular distance (3.47 angstrom) of the charge transfer pairs. Hence, the concomitant superior charge transfer interaction between pyrene/NDI can be attained and the resultant photothermal conversion efficiency of Py@Ca-NDI in aqueous solution can thus reach up to 41.8 %, which, to the best of our knowledge, is the highest value among the reported organic co-crystal materials; it is also much higher than that of the FDA approved photothermal agent ICG as well as most of the reported MOFs. Based on this realization, as a proof of concept, we demonstrated that such a self-assembled organic co-crystal platform can be used in biological applications that are exemplified via highly effective long wavelength light photothermal therapy.
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