期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 37, 页码 20215-20219出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202106145
关键词
alkene difunctionalization; alkyne; allenyl radical; radical reactions; rearrangement
资金
- National Natural Science Foundation of China [21971173]
- Project of Scientific and Technologic Infrastructure of Suzhou [SZS201905]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
The radical-mediated difunctionalization of alkenes introduces one alkenyl or alkynyl group to target compounds, but simultaneous installation of two unsaturated C-C bonds via alkene difunctionalization remains challenging due to the high instability of alkenyl and alkynyl radicals. This study reports the successful photocatalytic 1,2-alkynylalkenylation and 1,2-enynylalkenylation of alkenes, utilizing stabilized allenyl radicals for intermolecular addition, with a broad substrate scope and increased degree of unsaturation.
Radical-mediated difunctionalization of alkenes provides a promising approach to introduce one alkenyl or alkynyl group to target compounds. However, simultaneous installation of two unsaturated C-C bonds via alkene difunctionalization remains elusive, attributable to the high instability and transient lifetimes of alkenyl and alkynyl radicals. Herein, we report the photocatalytic 1,2-alkynylalkenylation and 1,2-enynylalkenylation of alkenes for the first time, triggered by the intermolecular addition of a stabilized allenyl radical to an alkene. A portfolio of strategically designed, easily accessible dual-function reagents are applied to a radical docking-migration cascade. The protocol has broad substrate scope and efficiently increases the degree of unsaturation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据