期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 47, 页码 24968-24975出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202108671
关键词
luminescent metal-organic frameworks; polyphenols; self-assembly; supramolecular chemistry; surface engineering
资金
- Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology [CE140100036]
- National Health and Medical Research Council Senior Principal Research Fellowship [GNT1135806]
- Netherlands Organisation for Scientific Research [019.182EN.034]
- JSPS KAKENHI [20F20373]
- JSPS [P20373]
- Austrian Science Fund (FWF) [P20373] Funding Source: Austrian Science Fund (FWF)
- Grants-in-Aid for Scientific Research [20F20373] Funding Source: KAKEN
The study introduces a novel fluorescence labeling strategy using luminescent metal-phenolic networks (MPNs) which can produce customized fluorescent coatings on various particles with stability and strong fluorescence, showing negligible cytotoxicity to cells. This approach has great potential for diverse applications in the fields of life sciences and physical sciences.
The development of fluorescence labeling techniques has attracted widespread interest in various fields, including biomedical science as it can facilitate high-resolution imaging and the spatiotemporal understanding of various biological processes. We report a supramolecular fluorescence labeling strategy using luminescent metal-phenolic networks (MPNs) constructed from metal ions, phenolic ligands, and common and commercially available dyes. The rapid labeling process (<5 min) produces ultrathin coatings (approximate to 10 nm) on diverse particles (e.g., organic, inorganic, and biological entities) with customized luminescence (e.g., red, blue, multichromatic, and white light) simply through the selection of fluorophores. The fluorescent coatings are stable at pH values from 1 to 8 and in complex biological media owing to the dominant pi interactions between the dyes and MPNs. These coatings exhibit negligible cytotoxicity and their strong fluorescence is retained even when internalized into intracellular compartments. This strategy is expected to provide a versatile approach for fluorescence labeling with potential in diverse fields across the physical and life sciences.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据