期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 44, 页码 23608-23613出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202110351
关键词
biocatalytic cascades; biosensors; enzymes immobilization; HOFs; point-of-care detection
资金
- National Natural Science Foundation of China [22174164, 22104159, 21904146]
- Natural Science Foundation of Guangdong Province [2020A1515010825, 2019A1515011722]
- Fundamental Research Funds for the Central Universities [2021qntd24]
The use of MHOFs as a protecting scaffold for organizing biocatalytic cascades has shown superior activity, expanded scope of catalytic substrates, and ultrahigh stability. The study also demonstrates the advantages of MHOF-confined cascades system for point-of-care biosensing.
Herein, we report the first example of using mesoporous hydrogen-bonded organic frameworks (MHOFs) as the protecting scaffold to organize a biocatalytic cascade. The confined microenvironment of MHOFs has robust and large transport channels, allowing the efficient transport of a wide range of biocatalytic substrates. This new MHOF-confined cascade system shows superior activity, extended scope of catalytic substrates, and ultrahigh stability that enables the operation of complex chemical transformations in a porous carrier. In addition, the advantages of MHOF-confined cascades system for point-of-care biosensing are also demonstrated. This study highlights the advantages of HOFs as scaffold for multiple enzyme assemblies, which has huge potential for mimicking complex cellular transformation networks in a controllable manner.
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