期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 35, 页码 19201-19206出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202103943
关键词
antibacterial agents; enzymes; mesoporous materials; photodynamic therapy; upconversion nanoparticles
资金
- Science and Technology Cooperation Fund between Chinese and Australian Governments [2017YFE0132300]
- Strategic Priority Research Program of the CAS [XDB20000000]
- NSFC [51672272, 21771185, 21771178, 21975257, 81572944, 81971983]
- Youth Innovation Promotion Association of CAS [2017347]
- CAS/SAFEA International Partnership Program for Creative Research Teams
The research team designed a bio-inorganic nanohybrid that combines lysozyme with the UCNP-PDT system to enhance the efficiency against drug-resistant bacteria. The nanoplatform achieves strong bactericidal capacity and significant bacteriostasis on methicillin-resistant S. aureus through rapid adhesion to bacteria, intelligently bacteria-responsive LYZ release, and synergistic LYZ-PDT effect.
The rapid emergence of drug-resistant bacteria has raised a great social concern together with the impetus for exploring advanced antibacterial ways. NIR-triggered antimicrobial photodynamic therapy (PDT) by lanthanide-doped upconversion nanoparticles (UCNP) as energy donor exhibits the advantages of high tissue penetration, broad antibacterial spectrum and less acquired resistance, but is still limited by its low efficacy. Now we designed a bio-inorganic nanohybrid and combined lysozyme (LYZ) with UCNP-PDT system to enhance the efficiency against resistant bacteria. Benefiting from the rapid adhesion to bacteria, intelligently bacteria-responsive LYZ release and synergistic LYZ-PDT effect, the nanoplatform achieves an exceptionally strong bactericidal capacity and conspicuous bacteriostasis on methicillin-resistant S. aureus. These findings pave the way for designing efficiently antibacterial nanomaterials and provide a new strategy for combating deep-tissue bacterial infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据