期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 38, 页码 20666-20671出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202105973
关键词
benzylamines; biomass; lignin; beta-O-4 model compounds
资金
- National Key R&D Program of China [2019YFC1905300]
- National Natural Science Foundation of China [22078317, 21878288, 21721004, 21690083]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB17020100]
- Royal Society International Collaboration Award [IC170044]
The study presents a new strategy for the direct transformation of lignin model compounds into benzylamines and phenols, with experimental data indicating the significance of dehydrogenation reaction and the role of secondary amines in the transformation. This work provides a novel opportunity for sustainable synthesis of benzylamines from renewable biomass, expanding the products pool of biomass conversion for future biorefinery demands.
Catalytic conversion of lignin into heteroatom functionalized chemicals is of great importance to bring the biorefinery concept into reality. Herein, a new strategy was designed for direct transformation of lignin beta-O-4 model compounds into benzylamines and phenols in moderate to excellent yields in the presence of organic amines. The transformation involves dehydrogenation of C-alpha-OH, hydrogenolysis of the C-beta-O bond and reductive amination in the presence of Pd/C catalyst. Experimental data suggest that the dehydrogenation reaction proceeds over the other two reactions and secondary amines serve as both reducing agents and amine sources in the transformation. Moreover, the concept of lignin to benzylamines was demonstrated by a two-step process. This work represents a first example of synthesis of benzylamines from lignin, thus providing a new opportunity for the sustainable synthesis of benzylamines from renewable biomass, and expanding the products pool of biomass conversion to meet future biorefinery demands.
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