4.4 Article

Taurine ameliorates cytotoxic effects of Di(2-ethylhexyl) phthalate on Leydig cells

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Multiple transcriptomic profiling: p53 signaling pathway is involved in DEHP-induced prepubertal testicular injury via promoting cell apoptosis and inhibiting cell proliferation of Leydig cells

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Summary: The research revealed that DEHP disrupts testicular development, lowers serum testosterone levels in prepubertal mice, induces cell apoptosis and cell cycle arrest in TM3 cells. The p53 signaling pathway plays a crucial role in DEHP-induced prepubertal testicular injuries by promoting cell apoptosis and inhibiting cell proliferation.

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