期刊
ANALYTICAL CHEMISTRY
卷 93, 期 39, 页码 13212-13218出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.1c02200
关键词
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资金
- National Natural Science Foundation of China [22175062, 21671064]
- Scientific Research Fund of Hunan Provincial Education Department [19A329]
- Natural Science Foundation of Hunan Province, China [2019JJ10002]
- Hunan Provincial Innovation Foundation For Postgraduate [CX20200521]
- Furong Scholars Programme of Hunan Province
The study introduces an endogenous H2S-triggered SiO2@Ag nanoprobe for in situ dual-modal NIR-II/PA imaging of colorectal cancer. The designed dual-modal nanoprobe can be converted to SiO2@Ag2S after in situ biosynthesis via a sulfuration reaction with the over-expressed endogenous H2S in the colorectal tumor. The designed SiO2@Ag nanoprobe exhibits high sensitivity and specificity for diagnosing colorectal cancer in vivo via dual-modal NIR-II/PA imaging, providing a new dual-modal imaging strategy for noninvasive intelligent detection of colorectal cancer.
An endogenous H2S-triggered intelligent optical nanoprobe combining second near-infrared (NIR-II) fluorescence with photoacoustic (PA) imaging can provide more comprehensive information to further improve the sensitivity and reliability of diagnosis for colorectal tumor, which is rarely explored. Herein, an endogenous H2S-triggered SiO2@Ag nanoprobe was designed for in situ dual-modal NIR-II/PA imaging of colorectal cancer. The designed dual-modal nanoprobe can be converted to SiO2@Ag2S after in situ biosynthesis via a sulfuration reaction with the over-expressed endogenous H2S in the colorectal tumor. More importantly, the designed SiO2@Ag nanoprobe exhibits high sensitivity and specificity for diagnosing colorectal cancer in vivo via dual-modal NIR-II/PA imaging. These results provide a new NIR-II/PA dual-modal imaging strategy for noninvasive intelligent detection of colorectal cancer.
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