期刊
ANALYTICAL CHEMISTRY
卷 93, 期 35, 页码 12059-12066出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.1c02310
关键词
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资金
- National Natural Science Foundation of China [51972001, 51772002, 21805001, 22001005, 22005001, 22005002]
- Changjiang Scholars and Innovative Research Team in University, Academician workstation of Anhui University, Anhui University Scientific Research Start-up Fund [S020118002/039, S020118002/089, S020318006/005]
- Key Laboratory of Photovoltaic and Energy Conservation Materials, Chinese Academy of Sciences [PECL2019KF012]
A theranostic platform based on the coumarin-based D-p-A system was developed in this study, revealing its intracellular delivery pathway and NIR-activated mitophagy, showing potential for complete cancer ablation in in vivo experiments under 808 nm irradiation.
Considering the multiple biological barriers before the entry of photosensitizers (PSs) into cytoplasm, it is of paramount importance to track PSs to elucidate their behaviors and distributions to guide the photodynamic therapy (PDT). Also, the developed PSs suffer from strong oxygen dependency. However, reports on such ideal theranostic platforms are rare. Herein, we developed a theranostic platform (CMTP-2) based on the coumarin-based D-p-A system, which, for the first time, can reveal the holistic intracellular delivery pathway and near-infrared (NIR)-activated mitophagy to guide synergistic type-I PDT and photothermal therapy. The dynamic endo-lysosomal escape of CMTP-2 was monitored, as well as its changeable distributions in endosomes, lysosomes, and mitochondria, demonstrating the preferential accumulation in mitochondria at the end. Upon NIR-I irradiation, CMTP-2 generated toxic radicals and heat, triggering the execution of mitophagy and apoptosis. In vivo experiments on mice indicated that CMTP-2 under 808 nm irradiation realized complete cancer ablation, showing great potential for advancements in synergistic phototherapy.
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