期刊
ANALYTICAL CHEMISTRY
卷 93, 期 29, 页码 10204-10211出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.1c01561
关键词
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资金
- NMR core facility of the Faculty of Chemistry, University of Vienna
- European Research Council (ERC) under the European Union [801936]
- FWF standalone grant [P-33338 N]
- CNRS-NTU Excellence Science Joint Research Program
- European Research Council (ERC) [801936] Funding Source: European Research Council (ERC)
The study reveals that simulated body fluids (SBFs) undergo dynamic nanoscopic conformational rearrangements and form nanoscale inhomogeneities of calcium phosphate (CaP) aggregates. These structures may act as precursors in the crystallization process and are crucial for understanding nonclassical crystallization phenomena.
Simulated body fluids (SBFs) that mimic human blood plasma are widely used media for in vitro studies in an extensive array of research fields, from biomineralization to surface and corrosion sciences. We show that these solutions undergo dynamic nanoscopic conformational rearrangements on the timescale of minutes to hours, even though they are commonly considered stable or metastable. In particular, we find and characterize nanoscale inhomogeneities made of calcium phosphate (CaP) aggregates that emerge from homogeneous SBFs within a few hours and evolve into prenucleation species (PNS) that act as precursors in CaP crystallization processes. These ionic clusters consist of similar to 2 nm large spherical building units that can aggregate into suprastructures with sizes of over 200 nm. We show that the residence times of phosphate ions in the PNS depend critically on the total PNS surface. These findings are particularly relevant for understanding nonclassical crystallization phenomena, in which PNS are assumed to act as building blocks for the final crystal structure.
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