期刊
ANALYTICAL CHEMISTRY
卷 93, 期 29, 页码 10122-10131出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.1c01010
关键词
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资金
- National Natural Science Foundation of China [21825402, 21575096, 21605109]
- Natural Science Foundation of Jiangsu Province of China [BK20191417]
- 111 Project
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
The silicon nanoparticles (SiNPs)-based exosome (SiNPs@EXO) probes can effectively distinguish normal and metastatic sentinel lymph nodes (SLNs), with a high fluorescence signal intensity and long duration marking metastatic SLNs. Compared to clinically used SLN tracers, SiNPs@EXO has better performance and fewer side effects.
Sentinel lymph node (SLN) detection is of great significance for the prevention and treatment of cancer metastasis. Herein, we introduce silicon nanoparticles (SiNPs)-based exosome (SiNPs@EXO) probes for distinguishing normal and metastatic SLNs. Typically, SiNPs are suitable for stable and long-term tracking of exosomes, while cancer cell-driven exosomes with a tumor-homing effect allow targeting metastatic SLNs. Remarkably, the as-fabricated SiNPs@EXO has the ability to label metastatic SLNs, i.e., the fluorescence signal in SLNs reaches the peak within 0.5 h and remains up to 3 h. Comparatively, SLN tracers (e.g., indocyanine green) used clinically can illuminate SLNs 1 h post injection, whereas the signal witnesses a sharp fall then. Moreover, evaluations based on preclinical data confirm the negligible side effects of the SiNPs@EXO. Our results provide new tools for targeting SLNs and predicting lymphatic metastasis of tumor.
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