期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 413, 期 25, 页码 6355-6364出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-021-03591-2
关键词
Ambient ionization; Triclosan; Direct analysis in real time (DART); Accurate mass spectrometry; Environmental samples; Matrix effects
资金
- CRUE-CSIC
- Springer Nature
The study examined the quantitative determination of triclosan (TCS) using direct analysis in real time coupled to accurate mass spectrometry (DART-MS) in samples of increasing complexity. The results showed that under final selected conditions, TCS could be determined with an instrumental limit of quantification of 5 ng mL(-1) and a linear response range up to 1000 ng mL(-1).
In this work, the applicability of direct analysis in real time coupled to accurate mass spectrometry (DART-MS) to the quantitative determination of triclosan (TCS) in samples with increasing complexity, from personal care products to extracts from sewage, is investigated. In the first term, DART-MS spectra of TCS as free phenol and as derivatized species are characterized; thereafter, the effects of several instrumental variables in the detectability of TCS (i.e., temperature, solvent, and compound holder) are discussed. Under final selected conditions, TCS was determined from its [M-H](-) ions, without need of derivatization, attaining an instrumental limit of quantification of 5 ng mL(-1), with a linear response range up to 1000 ng mL(-1). Complex matrices, such as solid-phase extracts obtained from environmental water samples, moderately inhibited the ionization efficiency of TCS, with signal attenuation percentages in the range of 6 to 57%, depending on the sample type and on the concentration factor provided by the SPE procedure. The accuracy of results obtained by DART-MS was evaluated using liquid chromatography (LC) with MS detection; in both cases, a time-of-flight (TOF) MS instrument was employed for the selective determination of the [M-H](-) ions of TCS (m/z values 286.9439 and 288.9410) using a mass window of 20 ppm. DART-MS did not only provide enough sensitivity to detect the presence of TCS in environmental samples (raw and treated wastewater as well as freeze-dried sludge), but also measured concentrations matched those determined by LC-ESI-TOF-MS, with only slightly higher standard deviations. During analysis of personal care products, containing much higher concentrations of TCS in a less complex matrix, both techniques were equivalent in terms of accuracy and precision.
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