NiCo-LDH nanoflake arrays-supported Au nanoparticles on copper foam as a highly sensitive electrochemical non-enzymatic glucose sensor

The detection of glucose in human blood is of great importance in the diagnosis and prevention of diabetes. In this work, we fabricated a novel electrochemical non-enzymatic glucose sensor, NiCo-LDH nanoflake arrays-supported Au nanoparticles on copper foam (NiCo-LDH@ Au/Cu) by galvanic replace-ment and electrodeposition methods. Owing to the synergistic effect of three-dimensional (3D) archi-tecture of Cu foam, high electrocatalytic activity of Au nanoparticles and NiCo-LDH nanoflake arrays, the NiCo-LDH@Au/Cu electrode exhibits excellent electrocatalytic ability for glucose oxidation in NaOH so-lution. Under optimized conditions, the NiCo-LDH@Au/Cu electrode shows excellent activity with a linear range from 0.5 to 3000 mM at the potential of 0.50 V (vs. Ag/AgCl), a low detection limit of 0.23 mM (S/N = 3), an ultra-prompt response time of 0.5 s, and a high sensitivity of 23100 mA mM(-1) cm(-2), as well as good selectivity and stability. Furthermore, the as-fabricated non-enzymatic glucose sensor was suc-cessfully applied to the glucose detection in human serum as a promising candidate in the development of electrochemical non-enzymatic glucose sensor. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

A novel electrochemical non-enzymatic glucose sensor, NiCo-LDH@Au/Cu electrode, was successfully fabricated with high electrocatalytic activity for glucose oxidation. The sensor exhibited a wide linear range, low detection limit, ultra-prompt response time, high sensitivity, good selectivity, and stability, making it a promising candidate for glucose detection in human serum.