期刊
ANAEROBE
卷 69, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.anaerobe.2021.102360
关键词
Fusobacterium necrophorum; Tonsillar carriage; Tonsillar flora; Zambia; Sweden; Geographical difference
类别
资金
- Swedish Government Funds for Clinical Research (ALF)
- Swedish International Development Cooperation Agency (SIDA)
- Folke Nordbring's Foundation
- Lund University Africa Cooperation
Recent studies have shown transient carriage of Fusobacterium necrophorum in adolescence and young adulthood in Europe and the US, but data from Africa is lacking. This study found a high tonsillar carriage rate of F. necrophorum in Swedish participants aged 15-25 years compared to Zambian participants, with rare tonsillar carriage in Zambian participants above 25 years old.
While Fusobacterium necrophorum historically has been considered normal tonsillar flora, recent studies from Europe and the US have suggested that carriage occur transiently in adolescence and young adulthood. However, no studies originating from Africa exist. In this cross-sectional study of tonsillar carriage of F. necrophorum, we aimed to investigate geographical differences in tonsillar carriage rates of F. necrophorum in healthy participants aged 15-25 years in Sweden and Zambia and further investigate the age distribution of tonsillar carriage in Zambia. Specimens were obtained by tonsillar swabs and analyzed with real-time PCR for F. necrophorum. In participants aged 15-25 years, tonsillar carriage was more common in Sweden 21/100 (21%) than in Zambia 6/192 (3%), p < 0.001. In Zambian participants aged above 25 years tonsillar carriage was rare 1/76 (1%). In conclusion, the high rate of tonsillar carriage in participants aged 15-25 years in Sweden has implications on the interpretation of tonsillar findings in patients with pharyngotonsillitis. Interestingly, a geographical difference was found with tonsillar car-riage rarely identified in Zambia. (c) 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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