Humoral and cellular immune response and safety of two-dose SARS-CoV-2 mRNA-1273 vaccine in solid organ transplant recipients

Article Immunology

Coronavirus Disease 2019 in Solid Organ Transplant: A Multicenter Cohort Study

Olivia S. Kates et al.

Summary: The mortality rate among SOT recipients hospitalized for COVID-19 was 20.5%, with age and underlying comorbidities being the major drivers of mortality, rather than measures related to immunosuppression intensity.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

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Article Biochemistry & Molecular Biology

T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Katie J. Ewer et al.

Summary: A single dose of the ChAdOx1 nCoV-19 vaccine can induce favorable immune responses that may help control or prevent SARS-CoV-2 infection.

NATURE MEDICINE (2021)

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Letter Medicine, General & Internal

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

Alicia T. Widge et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Surgery

Safety and immunogenicity of adjuvanted recombinant subunit herpes zoster vaccine in lung transplant recipients

Cedric Hirzel et al.

Summary: The study investigated the safety and immunogenicity of a recombinant zoster vaccine (RZV) in lung transplant recipients, demonstrating that RZV was safe and elicited significant humoral and cell-mediated immunity in this population, making it a new option for preventing shingles in this group.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Microbiology

A New SARS-CoV-2 Dual-Purpose Serology Test: Highly Accurate Infection Tracing and Neutralizing Antibody Response Detection

Sean C. Taylor et al.

Summary: The cPass surrogate virus neutralization test (sVNT) is a highly accurate tool for monitoring SARS-CoV-2 immunity, providing valuable assistance in surveillance of infected/recovered and/or vaccinated individuals, as well as in drug and convalescent-phase donor screening. The data also suggest potential applications for calibrating live-cell neutralization tests and longitudinal testing of recovered and/or vaccinated patients.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Article Immunology

Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection

Nina Le Bert et al.

Summary: The efficacy of virus-specific T cells in clearing pathogens involves a delicate balance between antiviral and inflammatory responses. Asymptomatic individuals clearing SARS-CoV-2 showed increased production of IFN-gamma and IL-2, along with a proportional secretion of IL-10 and proinflammatory cytokines, while symptomatic individuals displayed a disproportionate secretion of inflammatory cytokines triggered by SARS-CoV-2-specific T cell activation.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Surgery

Long-term shedding of viable SARS-CoV-2 in kidney transplant recipients with COVID-19

Ilies Benotmane et al.

Summary: The study found that a significant proportion of kidney transplant recipients can shed viable SARS-CoV-2 for at least 3 weeks after being infected with COVID-19, which may favor the emergence of new variants. Based on these findings, it is recommended to extend the isolation of kidney transplant recipients with COVID-19 until negative SARS-CoV-2 RT-PCR testing.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Letter Medicine, General & Internal

Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients

Brian J. Boyarsky et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Gastroenterology & Hepatology

Low immunogenicity to SARS-CoV-2 vaccination among liver transplant recipients

Liane Rabinowich et al.

Summary: Liver transplant recipients showed significantly lower immunological response to the Pfizer-BioNTech SARS-CoV-2 mRNA-based vaccine, with less than half developing sufficient levels of antibodies and lower average antibody levels compared to healthy controls. Predictors for non-response included older age, renal function and immunosuppressive medications.

JOURNAL OF HEPATOLOGY (2021)

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Article Biochemistry & Molecular Biology

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

David S. Khoury et al.

Summary: The level of neutralizing antibodies is closely related to immune protection against COVID-19, playing a crucial role in protecting against detected infection and severe infection. Studies have shown that neutralizing titers will decline over time after vaccination, leading to decreased protection against SARS-CoV-2 infection.

NATURE MEDICINE (2021)

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Letter Critical Care Medicine

Early humoral response among lung transplant recipients vaccinated with BNT162b2 vaccine

Yael Shostak et al.

LANCET RESPIRATORY MEDICINE (2021)

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Letter Surgery

Reduced humoral response to mRNA SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients without prior exposure to the virus: Not alarming, but should be taken gravely

Ayelet Grupper et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Cardiac & Cardiovascular Systems

Immunogenicity of BNT162b2 mRNA COVID-19 vaccine and SARS-CoV-2 infection in lung transplant recipients

Jan Havlin et al.

Summary: Transplant recipients showed weaker antibody response to mRNA COVID-19 vaccine compared to natural infection, with only a subset of patients demonstrating SARS-CoV-2 specific T-cell response. Further research is needed to identify the optimal vaccine type and schedule for immunocompromised transplant patients.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2021)

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Article Medicine, Research & Experimental

Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients

Arne Sattler et al.

Summary: The study analyzed immune responses in kidney transplant recipients after receiving the BNT162b2 vaccine, finding weaker antibody responses in transplant patients compared to healthy individuals and most hemodialysis patients. Additionally, spike-specific T cell responses were significantly reduced in transplant patients, indicating a need for revised vaccination strategies in immunosuppressed individuals.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Microbiology

Comparative Performance of Five Commercially Available Serologic Assays To Detect Antibodies to SARS-CoV-2 and Identify Individuals with High Neutralizing Titers

Eshan U. Patel et al.

Summary: Accurate serological assays are crucial for detecting SARS-CoV-2 antibodies, but commercial EIAs may not always accurately detect high nAb titers in individuals, indicating the limitations of current diagnostic methods for COVID-19 convalescent plasma donation.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Article Surgery