期刊
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
卷 321, 期 1, 页码 E130-E145出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00158.2021
关键词
heart; insulin; metabolism; signal transduction
资金
- National Institutes of Health [RO1-HL127764, RO1-HL112413, RO1-HL12357, R01-HL108379, R01-DK092065, U01-HL087947, RO1-HL73167, RO1-HL074259, R21-DK073590, U01-HL70525, R03-DK058073, R21-HL62886]
- American Heart Association EIA [16SFRN31810000, 20SFRN3512012]
- American Diabetes Association
Insulin receptors play a critical role in regulating cardiac growth, survival, substrate uptake, and mitochondrial metabolism. Altered insulin signaling in the heart can contribute to ventricular remodeling and heart failure progression. Understanding the role of insulin signaling in cardiac physiology and pathology may have therapeutic implications for conditions like obesity and diabetes.
Insulin receptors are highly expressed in the heart and vasculature. Insulin signaling regulates cardiac growth, survival, substrate uptake, utilization, and mitochondrial metabolism. Insulin signaling modulates the cardiac responses to physiological and pathological stressors. Altered insulin signaling in the heart may contribute to the pathophysiology of ventricular remodeling and heart failure progression. Myocardial insulin signaling adapts rapidly to changes in the systemic metabolic milieu. What may initially represent an adaptation to protect the heart from carbotoxicity may contribute to amplifying the risk of heart failure in obesity and diabetes. This review article presents the multiple roles of insulin signaling in cardiac physiology and pathology and discusses the potential therapeutic consequences of modulating myocardial insulin signaling.
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