期刊
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
卷 186, 期 4, 页码 209-227出版社
WILEY
DOI: 10.1002/ajmg.b.32863
关键词
animal experimental model; behavioral phenotype; biological mechanism; schizophrenia
资金
- National Natural Science Foundation of China [31371298]
- Natural Science Basic Research Plan in Shaanxi Province of China [2019JM-098]
- Scientific Research Funds of Xi'an No.3 Hospital [SYF2020003]
Schizophrenia is a common but serious mental illness with unclear pathogenesis, and effective animal experimental models are essential for research. There are four categories of experimental animal models that can better mimic clinical symptoms and gene-environment interactions, each with its own advantages and disadvantages. Careful selection of these models is crucial in research applications.
Schizophrenia is a relatively common but serious mental illness that results in a heavy burden to patients, their families, and society. The disease can be triggered by multiple factors, while the specific pathogenesis remains unclear. The development of effective therapeutic drugs for schizophrenia relies on a comprehensive understanding of the basic biology and pathophysiology of the disease. Therefore, effective animal experimental models play a vital role in the study of schizophrenia. Based on different molecular mechanisms and modeling methods, the currently used experimental animal experimental models of schizophrenia can be divided into four categories that can better simulate the clinical symptoms and the interplay between susceptible genes and the environment: neurodevelopmental, drug-induced, genetic-engineering, and genetic-environmental interaction of animal experimental models. Each of these categories contains multiple subtypes, which has its own advantages and disadvantages and therefore requires careful selection in a research application. The emergence and utilization of these models are promising in the prediction of the risk of schizophrenia at the molecular level, which will shed light on effective and targeted treatment at the genetic level.
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