期刊
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
卷 30, 期 3, 页码 332-337出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jagp.2021.07.012
关键词
Late-life depression; frailty; circulating cell-free mitochondrial DNA; mitochondria dysfunction; cellular stress; aging
资金
- National Institute of Mental Health [R01MH115953]
- CAMH, Toronto, ON, Canada
- Travelers Chair in Geriatrics and Gerontology
This study evaluated the levels of circulating cell-free mitochondrial DNA (ccf-mtDNA), a marker of cellular stress and damage, in older adults with late-life depression (LLD) and frailty. The coexistence of LLD and frailty was associated with higher levels of ccf-mtDNA, suggesting a common biological mechanism of cellular stress and mitochondrial dysfunction. This finding offers potential opportunities for future interventions guided by geroscience.
Objective: To evaluate the circulating cell-free mitochondrial DNA (ccf-mtDNA) levels, a marker of cellular stress and damage, in older adults with late-life depression (LLD) and frailty. We hypothesize that individuals with both frailty and LLD will have higher ccf-mtDNA levels than individuals with either condition in isolation. Methods: Fifty-three older adults (Never Depressed+Robust (reference group, n = 16), LLD+Robust (n = 9), Never Depressed+Prefrail/Frail (n = 5), and LLD+Prefrail/Frail (n = 23)) were included in the study. DNA was extracted from EDTA plasma samples, and ccf-mtDNA was quantified by RT-PCR. Results: We found a statistically significant difference in the levels of ccf-mtDNA across groups (F(3,49) = 3.07, p = 0.036), with individuals in the LLD+Prefrail/Frail group showing the highest levels of ccf-mtDNA. Conclusion: The coexistence of LLD and frailty is associated with increased markers of cellular damage and stress (i.e., ccf-mtDNA). Our results suggest that these conditions may share cellular stress and mitochondrial dysfunction phenomena as a common biological mechanism, offering potential future opportunities for geroscience-guided interventions for these conditions.
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