4.3 Review

Sessile Serrated Adenoma With Dysplasia of the Colon A Retrospective Pathology Review Focusing on Subtypes

期刊

AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 157, 期 2, 页码 180-195

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/ajcp/aqab112

关键词

Sessile; Serrated; Adenoma; Lesion; Colon; Dysplasia

向作者/读者索取更多资源

This study aimed to explore the relative percentages and significance of subtypes of sessile serrated adenomas with dysplasia (SSADs) in the colon. The results showed that while some trends exist, morphologically subclassifying SSADs is probably not justified in routine clinical practice. Loss of MLH1 indicates an increased burden of sessile serrated adenomas in the background colon.
Objectives Sessile serrated adenomas with dysplasia (SSADs) of the colon are transitional lesions between sessile serrated adenomas (SSAs) and a subset of colorectal adenocarcinomas. We wished to gain insight into the relative percentages and significance of SSAD subtypes. Methods Retrospective (2007-2012) clinicopathologic review of colorectal polyps initially regarded as having mixed serrated and dysplastic elements. SSADs were subdivided into those with cap-like adenomatous dysplasia (ad1), non-cap-like adenomatous dysplasia (ad2), serrated dysplasia (ser), minimal dysplasia (min), and dysplasia not otherwise specified (nos). MLH1 immunostaining was performed on many. Results SSADser (7.7%) had a greater propensity for right colon, women, and MLH1 loss vs the entire cohort. SSAad1 (11.6%) had the least female preponderance, was least likely to have MLH1 loss, and was most likely to affect the left colorectum. SSAD with MLH1 loss was associated with an increased burden of SSAs in the background colon (P = .0003) but not tubular adenomas or hyperplastic polyps. Most SSADs (ad2 and nos groups, 80% combined) showed difficult-to-classify dysplasia, intermediate MLH1 loss rates, and intermediate clinical features. Conclusions While some trends exist, morphologically subclassifying SSADs is probably not justified in routine clinical practice. MLH1 loss portends a greater burden of SSAs in the background colon.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据