How I Diagnose Angioimmunoblastic T-Cell Lymphoma

Objectives: Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma derived from T-follicular helper cells. For pathologists, diagnosing AITL may be challenging due to its wide clinical and histopathologic spectrum, which can mimic a variety of reactive and neoplastic processes. Methods: We summarize and discuss the clinicopathologic features of AITL, emphasizing diagnostic tools available to the practicing pathologist. Common diagnostic dilemmas are discussed. Results: AITL exhibits various histologic patterns and is often associated with a prominent microenvironment that can obscure the neoplastic cells. Atypical B-cell proliferations, which can take a number of ,form .g are common in AITL, and clonal B-cell expansion can be seen. The atypical B cells can closely resemble HodgkinI Reed-Sternberg cells, leading to misdiagnosis as classic Hodgkin lymphoma. Molecular studies have revealed recurrent genetic alterations, which can aid in differential diagnosis, particularly in problematic cases. Conclusions: Given the complex diagnostic challenges in AITL, an integrated approach, incorporating clinical, morphologic, immunophenotypic, and molecular findings, is helpful to reach an accurate diagnosis.

Automated summary

AITL, a subtype of peripheral T-cell lymphoma derived from T-follicular helper cells, poses diagnostic challenges due to its wide clinical and histopathologic spectrum. Diagnostic tools and molecular studies play crucial roles in aiding accurate diagnosis and differential diagnosis.