期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 114, 期 4, 页码 1342-1350出版社
OXFORD UNIV PRESS
DOI: 10.1093/ajcn/nqab188
关键词
TMAO; diet; fish; whole-grain cereals; long-chain n-3 fatty acids; dietary polyphenols; cardiometabolic risk factors
资金
- European Community's Seventh Framework Programme FP7/2009-2012 [FP7-KBBE222639]
- Etherpaths Project
- Ministero Istruzione Universita e Ricerca [PRIN 2010-2011-2010JCWWKM]
- European Commission's Sixth Framework Programme, Project HEALTHGRAIN [FOOD-CT2005-514008]
The study found that diets rich in long-chain n-3 fatty acids or whole-grain cereals can significantly increase plasma TMAO concentration, directly correlated with intakes of fish and whole-grain products.
Background: Plasma trimethylamine N-oxide (TMAO) has drawn much attention as a marker of several chronic diseases. Data on the relation between diet and TMAO arc discordant and few human intervention studies have assessed causality for this association. Objectives: We aimed to evaluate the effects on plasma TMAO of diets based on foods rich in polyphenols (PP) and/or long-chain n-3 fatty acids (LCn3) or whole-grain cereals (WGCs), in individuals at high cardiometabolic risk. Methods: An ancillary study was performed within 2 randomized controlled trials, aimed at evaluating the medium-term effects on cardiometabolic risk factors of diets naturally rich in PP and/or LCn3 (Etherpaths Project) or WGCs (HealthGrain Project). Results: In the Etherpaths study (n = 78), the changes in TMAO (8-wk minus baseline) were statistically significant for the diets rich in LCn3 (+1.15 +/- 11.58 mu mol/L) (P = 0.007), whereas they were not for the diets rich in PP (-0.14 +/- 3= 9.66 mu mol/L) (P = 0.905) or their interaction (P = 0.655) (2-factor ANOVA). In the HealthGrain Study (n = 48), the TMAO change (12-wk minus baseline) in the WGC group (+0.94 +/- 3.58 mu mol/L) was significantly different from that in the Refined Cereal group (-1.29 +/- 3.09 mu mol/L) (P = 0.037). Considering the pooled baseline data of the participants in the 2 studies, TMAO concentrations directly correlated with LCn3. EPA (20:5n-3), and protein intake, but not SFAs, fiber, MUFAs. and PP intake. Among food groups, TMAO directly correlated with the intake of fish, vegetables, and whole-grain products, but not meat. processed meat, and dairy products. Conclusions: Diets rich in LCn3 of marine origin or WGCs significantly increased plasma TMAO concentration. These changes mirrored the direct associations between TMAO concentrations and intakes of fish and WGCs, suggesting that TMAO reflects intakes of these healthy foods and, therefore, it is not a universally valid biomarker of cardiometabolic risk independent of the background diet.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据