期刊
ALZHEIMERS & DEMENTIA
卷 18, 期 6, 页码 1155-1163出版社
WILEY
DOI: 10.1002/alz.12462
关键词
Alzheimer's disease; dementia; epidemiology; family design; neurodevelopmental disorder
资金
- Swedish Council for Health, Working Life and Welfare [2019-00176, 2019-01172]
- Swedish Research Council [2018-02599]
- Swedish Brain Foundation [FO2018-0273]
- European Union [1754285]
- Fredrik& Ingrid Thurings Stiftelse
- Karolinska Institutet Research Foundation
- Forte [2019-00176] Funding Source: Forte
- Vinnova [2019-00176] Funding Source: Vinnova
The study found an intergenerational association between attention-deficit/hyperactivity disorder (ADHD) and Alzheimer's disease (AD) and other forms of dementia and neurodegenerative diseases, with the association weakening with decreasing genetic relatedness.
Introduction We examined the extent to which attention-deficit/hyperactivity disorder (ADHD), a neurodevelopmental disorder, is linked with Alzheimer's disease (AD) and any dementia, neurodegenerative diseases, across generations. Methods A nationwide cohort born between 1980 and 2001 (index persons) were linked to their biological relatives (parents, grandparents, uncles/aunts) using Swedish national registers. We used Cox models to examine the cross-generation associations. Results Among relatives of 2,132,929 index persons, 3042 parents, 171,732 grandparents, and 1369 uncles/aunts had a diagnosis of AD. Parents of individuals with ADHD had an increased risk of AD (hazard ratio 1.55, 95% confidence interval 1.26-1.89). The associations attenuated but remained elevated in grandparents and uncles/aunts. The association for early-onset AD was stronger than late-onset AD. Similar results were observed for any dementia. Discussion ADHD is associated with AD and any dementia across generations. The associations attenuated with decreasing genetic relatedness, suggesting shared familial risk between ADHD and AD.
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