4.7 Article

Patterns of tau pathology identified with 18F-MK-6240 PET imaging

期刊

ALZHEIMERS & DEMENTIA
卷 18, 期 2, 页码 272-282

出版社

WILEY
DOI: 10.1002/alz.12384

关键词

Alzheimer's disease; amyloid positivity; cerebrospinal fluid; cognition; MK-6240; tau positron emission tomography; tau positivity

资金

  1. NIA [K23AG052633, RF1AG058067, R01AG050440, RF1AG051556-01S2, K24AG045334, R01AG026158, RF1AG038465, K99AG065506, R01AG055422]
  2. Columbia University's CTSA [UL1TR000040]
  3. Washington Heights-Inwood Columbia Aging Project [WHICAP, P01AG07232, R01AG037212, RF1AG054023]
  4. Columbia University Alzheimer's Disease Research Center [P50AG008702]

向作者/读者索取更多资源

F-18-MK-6240 showed good correlation with CSF tau and p-tau levels, as well as age, cognition, and amyloid-based AD biomarkers. The study also found that F-18-MK-6240 binding patterns were associated with specific cognitive impairments in amyloid-positive participants, reflecting the progression of AD pathology.
Introduction: Positron emission tomography (PET) imaging for neurofibrillary tau allows investigation of the in vivo spatiotemporal progression of Alzheimer's disease (AD) pathology. We evaluated the suitability of F-18-MK-6240 in a clinical sample and determined the relationships among F-18-MK-6240 binding, age, cognition, and cerebrospinal fluid (CSF)-based AD biomarkers. Methods: Participants (n = 101, 72 +/- 9 years, 52% women) underwent amyloid PET, tau PET, structural T1-weighted magnetic resonance imaging, and neuropsychological evaluation. Twenty-one participants had lumbar puncture for CSF measurement of amyloid beta (A beta)(42), tau, and phosphorylated tau (p-tau). Results: F-18-MK-6240 recapitulated Braak staging and correlated with CSF tau and p-tau, normalized to A beta(42). F-18-MK-6240 negatively correlated with age across Braak regions in amyloid-positive participants, consistent with greater tau pathology in earlier onset AD. Domain-specific, regional patterns of F-18-MK-6240 binding were associated with reduced memory, executive, and language performance, but only in amyloid-positive participants. Discussion: F-18-MK-6240 can approximate Braak staging across the AD continuum and provide region-dependent insights into biomarker-based AD models.

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