期刊
ALLERGY
卷 77, 期 2, 页码 609-618出版社
WILEY
DOI: 10.1111/all.14987
关键词
asthma; epidemiology; IgE
资金
- Inserm Aviesan Itmo sante publique, the Scientific committee AGIR for chronic diseases [ANR-19-CE36-0005-01]
- Austrian Science Fund (FWF) [F4605]
- Country of Lower Austria
- Megagrant of the Government of the Russian Federation [14.W03.31.0024]
- European Commission's Seventh Framework Program MeDALL [261357]
- Agence Nationale de la Recherche (ANR) [ANR-19-CE36-0005] Funding Source: Agence Nationale de la Recherche (ANR)
This study identified four molecular sensitization profiles which remained stable from childhood to adulthood, and these profiles were associated with respiratory health outcomes such as asthma and rhinitis.
Background Longitudinal studies assessing the association of profiles of allergen-specific IgE (sIgE) sensitization to a large range of allergen molecules and respiratory health are rare. We aimed to assess trajectories of molecular sIgE sensitization profiles from childhood to adulthood and their associations with respiratory health. Methods IgE reactivity to microarrayed allergen molecules were measured in childhood (EGEA1) and 12 years later in adult life (EGEA2) among 291 EGEA participants (152 with asthma). At each time point, sIgE sensitization profiles were identified by latent class analysis (LCA) by considering IgE-reactivity to the 38 most prevalent respiratory allergens. The LCA-defined profiles were then studied in association with respiratory health. Results At baseline, the mean (min-max) age of the population was 11 (4.5-16) years. The LCA identified four sIgE sensitization profiles which were very similar at both time points (% at EGEA1 and EGEA2); A: no/few allergen(s) (48%, 39%), B: pollen/animal allergens (18%, 21%), C: most prevalent house dust mite allergens (22%, 27%) and D: many allergens (12%, 13%). Overall, 73% of the participants remained in the same profile from childhood to adulthood. The profiles were associated with asthma and rhinitis phenotypes. Participants of profiles C and D had lower FEV1% and FEF25-75% as compared to profile A. Similar patterns of associations were observed for participants with asthma. There was no association with change in lung function. Conclusion Using high-resolution sIgE longitudinal data, the LCA identified four molecular sensitization profiles, mainly stable from childhood to adulthood, that were associated with respiratory health.
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