期刊
AIDS
卷 35, 期 15, 页码 2513-2522出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0000000000003061
关键词
aging; bone; HIV; MSM; women
资金
- MWCCS: Atlanta CRS [U01-HL146241]
- Baltimore CRS [U01-HL146201]
- Bronx CRS [U01-HL146204]
- Brooklyn CRS [U01-HL146202]
- Data Analysis and Coordination Center [U01-HL146193]
- Chicago-Cook County CRS [U01-HL146245]
- Chicago-Northwestern CRS [U01-HL146240]
- Northern California CRS [U01-HL146242]
- Los Angeles CRS [U01-HL146333]
- Metropolitan Washington CRS [U01-HL146205]
- Miami CRS [U01-HL146203]
- Pittsburgh CRS [U01-HL146208]
- UAB-MS CRS [U01-HL146192]
- UNC CRS [U01HL146194]
- National Heart, Lung, and Blood Institute (NHLBI)
- Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD)
- National Institute On Aging (NIA)
- National Institute Of Dental & Craniofacial Research (NIDCR)
- National Institute Of Allergy And Infectious Diseases (NIAID)
- National Institute Of Neurological Disorders And Stroke (NINDS)
- National Institute on Deafness and Other Communication Disorders (NIDCD)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institute on Minority Health and Health Disparities (NIMHD)
- National Institutes of Health, Office of AIDS Research (OAR)
- UCSF CTSA [UL1-TR000004]
- JHU ICTR [UL1-TR003098]
- UCLA-CTSI [UL1-TR001881]
- Atlanta CFAR [P30-AI-050409]
- UNC CFAR [P30-AI-050410]
- UAB CFAR [P30-AI-027767]
In men who have sex with men (MSM), HIV status did not have a significant impact on hip bone structure, although cortical thickness was lower than expected overall. However, in women, those with HIV had significantly lower cortical thickness, integral bone mineral density, and trabecular bone mineral density across all quadrants compared to those without HIV.
Objective: To investigate HIV-related and age-related differences in hip bone structure in men and women. Design: Cross sectional study of bone structure and HIV serostatus. Methods: We used Quantitative Computed Tomography (QCT) data from the Multicenter AIDS Cohort Study (MACS) and Women's Interagency HIV Study (WIHS) to examine cortical thickness (CT) and cortical (CBMD), trabecular (TBMD), and integral (IBMD) bone mineral density across anatomic quadrants of the femoral neck in older adult MSM and women with (PWH) and without (PWOH) HIV infection. The percentage difference (%diff) in the means for CT and BMD overall and by quadrant between PWH and PWOH were estimated. Results: Among 322 MSM (median age 60 years) with bone measures, distributions were similar between HIV serostatus groups with %diff in the quadrant means ranging from -7 to -1% for CT and from -1 to 4% for BMD, and overall lower hip cortical thickness than expected. In contrast, in 113 women (median age 51 years), PWH had lower CT, IBMD and TBMD consistently across all quadrants, with differences ranging from -10 to -20% for CT, -6 to -11% for IBMD and -3 to -6% for TBMD. Estimates reached statistical significance in superoanterior quadrant for CT and IBMD and inferoposterior for CT. Conclusion: Among women, PWH appear to have a thinner cortex and less dense integral bone compared with PWOH, particularly in the superior quadrants whereas MSM overall had a thinner than expected hip cortex.
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