期刊
AGING-US
卷 13, 期 12, 页码 16024-16042出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.203121
关键词
prostate adenocarcinoma; biochemical recurrence; gene expression; tumor microenvironment; targeted maximum likelihood estimation
资金
- National Natural Science Foundation of China [81773547, 82003557]
- Shandong Provincial Natural Science Foundation of China [ZR2019ZD02]
- Shandong Provincial Key Research and Development project [2018CXGC1210]
The study aimed to identify potential prognostic genes in the prostate adenocarcinoma microenvironment and found 14 genes related to prognosis, which were associated with immune responses. These findings may contribute to improved prognosis in prostate adenocarcinoma.
Prostate adenocarcinoma is one of the leading adult malignancies. Identification of multiple causative biomarkers is necessary and helpful for determining the occurrence and prognosis of prostate adenocarcinoma. We aimed to identify the potential prognostic genes in the prostate adenocarcinoma microenvironment and to estimate the causal effects simultaneously. We obtained the gene expression data of prostate adenocarcinoma from TCGA project and identified the differentially expressed genes based on immune-stromal components. Among these genes, 68 were associated with biochemical recurrence at 3 years after prostatectomy in prostate adenocarcinoma. After adjusting for the minimal sets of confounding covariates, 14 genes (TNFRSF4, ZAP70, ERMN, CXCL5, SPINK6, SLC6A18, CHRM2, TG, CLLU1OS, POSTN, CTSG, NETO1, CEACAM7, and IGLV3-22) related to the microenvironment were identified as prognostic biomarkers using the targeted maximum likelihood estimation. Both the average and individual causal effects were obtained to measure the magnitude of the effect. CIBERSORT and gene set enrichment analyses showed that these prognostic genes were mainly associated with immune responses. POSTN and NETO1 were correlated with androgen receptor expression, a main driver of prostate adenocarcinoma progression. Finally, five genes were validated in another prostate adenocarcinoma cohort (GEO: GSE70770). These findings might lead to the improved prognosis of prostate adenocarcinoma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据