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Pioglitazone ameliorates Aβ42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3β activation
Sisi Yang et al.
MOLECULAR MEDICINE REPORTS (2017)
Inflammation, metaflammation and immunometabolic disorders
Gokhan S. Hotamisligil
NATURE (2017)
Microglia emerge as central players in brain disease
Michael W. Salter et al.
NATURE MEDICINE (2017)
Search for risk genes in Alzheimer's disease
I. Karaca et al.
NERVENARZT (2017)
Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease
Natalia Mast et al.
NEUROPHARMACOLOGY (2017)
A four-day Western-style dietary intervention causes reductions in hippocampal-dependent learning and memory and interoceptive sensitivity
Tuki Attuquayefio et al.
PLOS ONE (2017)
The relationship between obesity and cognitive health and decline
Louise Dye et al.
PROCEEDINGS OF THE NUTRITION SOCIETY (2017)
The Hippocampus and the Regulation of Human Food Intake
Richard J. Stevenson et al.
PSYCHOLOGICAL BULLETIN (2017)
Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration
Eduardo Rojas-Gutierrez et al.
SYNAPSE (2017)
The blood brain barrier in Alzheimer's disease
A. Chakraborty et al.
VASCULAR PHARMACOLOGY (2017)
On the path to 2025: understanding the Alzheimer's disease continuum
Paul S. Aisen et al.
ALZHEIMERS RESEARCH & THERAPY (2017)
The role of microbial amyloid in neurodegeneration
Robert P. Friedland et al.
PLOS PATHOGENS (2017)
Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains
Douglas M. Zeppenfeld et al.
JAMA NEUROLOGY (2017)
Intermittent Fasting Protects against Alzheimer's Disease Possible through Restoring Aquaporin-4 Polarity
Jingzhu Zhang et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)
T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer's Disease: Potential Pools of New Biomarkers
Anna Mietelska-Porowska et al.
JOURNAL OF IMMUNOLOGY RESEARCH (2017)
Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice
Kyong Nyon Nam et al.
SCIENTIFIC REPORTS (2017)
Gut microbiome alterations in Alzheimer's disease
Nicholas M. Vogt et al.
SCIENTIFIC REPORTS (2017)
Adipose tissue inflammation in obesity: a metabolic or immune response?
Emilie Stolarczyk
CURRENT OPINION IN PHARMACOLOGY (2017)
Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition
Philip C. Calder et al.
AGEING RESEARCH REVIEWS (2017)
Clearance of cerebral Aβ in Alzheimer's disease: reassessing the role of microglia and monocytes
Leah Zuroff et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2017)
The blood-brain barrier in systemic inflammation
Aravinthan Varatharaj et al.
BRAIN BEHAVIOR AND IMMUNITY (2017)
Microglial M1/M2 polarization and metabolic states
Ruben Orihuela et al.
BRITISH JOURNAL OF PHARMACOLOGY (2016)
A high-sugar high-fat diet induced metabolic syndrome shows some symptoms of Alzheimer's disease in rats
L. Niu et al.
JOURNAL OF NUTRITION HEALTH & AGING (2016)
The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies
Emilio Pedditizi et al.
AGE AND AGEING (2016)
Apolipoprotein E4 association with metabolic syndrome depends on body fatness
Elena Torres-Perez et al.
ATHEROSCLEROSIS (2016)
Saturated fatty acids trigger TLR4-mediated inflammatory response
D. M. Rocha et al.
ATHEROSCLEROSIS (2016)
Western Diets Induce Blood-Brain Barrier Leakage and Alter Spatial Strategies in Rats
Sara L. Hargrave et al.
BEHAVIORAL NEUROSCIENCE (2016)
Short-term exposure to a diet high in fat and sugar, or liquid sugar, selectively impairs hippocampal-dependent memory, with differential impacts on inflammation
J. E. Beilharz et al.
BEHAVIOURAL BRAIN RESEARCH (2016)
Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease
Amy R. Nelson et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)
Membrane raft domains and remodeling in aging brain
Julie Colin et al.
BIOCHIMIE (2016)
Imbalanced cholesterol metabolism in Alzheimer's disease
Zhao Xue-shan et al.
CLINICA CHIMICA ACTA (2016)
High-fat diet feeding differentially affects the development of inflammation in the central nervous system
Owein Guillemot-Legris et al.
JOURNAL OF NEUROINFLAMMATION (2016)
Non-alcoholic fatty liver disease induces signs of Alzheimer's disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model
Do-Geun Kim et al.
JOURNAL OF NEUROINFLAMMATION (2016)
Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease
Hong Lian et al.
JOURNAL OF NEUROSCIENCE (2016)
Mango Supplementation Modulates Gut Microbial Dysbiosis and Short-Chain Fatty Acid Production Independent of Body Weight Reduction in C57BL/6Mice Fed a High-Fat Diet
Babajide Ojo et al.
JOURNAL OF NUTRITION (2016)
Diet-microbiota interactions as moderators of human metabolism
Justin L. Sonnenburg et al.
NATURE (2016)
Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease
Weiguo Peng et al.
NEUROBIOLOGY OF DISEASE (2016)
Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease
Leah C. Graham et al.
SCIENTIFIC REPORTS (2016)
Impact of Dietary Lipids on Colonic Function and Microbiota: An Experimental Approach Involving Orlistat-Induced Fat Malabsorption in Human Volunteers
Pamela Morales et al.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2016)
Sexually dimorphic brain fatty acid composition in low and high fat diet-fed mice
Carlos Rodriguez-Navas et al.
MOLECULAR METABOLISM (2016)
Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation
Gabriella Testa et al.
REDOX BIOLOGY (2016)
Adipose Tissue Remodeling: its Role in energy Metabolism and Metabolic Disorders
Sung Sik Choe et al.
FRONTIERS IN ENDOCRINOLOGY (2016)
Gut microbiome and metabolic syndrome
Mohsen Mazidi et al.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2016)
27-Hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice
Maura Heverin et al.
BEHAVIOURAL BRAIN RESEARCH (2015)
Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance
Pedro Cisternas et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)
Obese-type Gut Microbiota Induce Neurobehavioral Changes in the Absence of Obesity
Annadora J. Bruce-Keller et al.
BIOLOGICAL PSYCHIATRY (2015)
Western diet is associated with a smaller hippocampus: a longitudinal investigation
Felice N. Jacka et al.
BMC MEDICINE (2015)
Monounsaturated Fatty Acid-Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome-Mediated IL-1β Secretion and Insulin Resistance Despite Obesity
Orla M. Finucane et al.
DIABETES (2015)
Cholesterol-induced astrocyte activation is associated with increased amyloid precursor protein expression and processing
Evangelina Avila-Munoz et al.
GLIA (2015)
Prevalence of the Metabolic Syndrome in the United States, 2003-2012
Maria Aguilar et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)
Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK)
Kenny L. Chan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit
William A. Banks et al.
JOURNAL OF NEUROINFLAMMATION (2015)
Host microbiota constantly control maturation and function of microglia in the CNS
Daniel Erny et al.
NATURE NEUROSCIENCE (2015)
Age- and location-related changes in microglial function
Rodney M. Ritzel et al.
NEUROBIOLOGY OF AGING (2015)
The Glymphatic System: A Beginner's Guide
Nadia Aalling Jessen et al.
NEUROCHEMICAL RESEARCH (2015)
Lipidomic Profiling of Liver Tissue from Obesity-Prone and Obesity-Resistant Mice Fed a High Fat Diet
Miso Nam et al.
SCIENTIFIC REPORTS (2015)
Plaque-associated lipids in Alzheimer's diseased brain tissue visualized by nonlinear microscopy
Juris Kiskis et al.
SCIENTIFIC REPORTS (2015)
Cholesterol metabolism and homeostasis in the brain
Juan Zhang et al.
PROTEIN & CELL (2015)
Neuroprotective Effects of Clostridium butyricum against Vascular Dementia in Mice via Metabolic Butyrate
Jiaming Liu et al.
BIOMED RESEARCH INTERNATIONAL (2015)
The effects of diet-induced obesity on B cell function
S. R. Shaikh et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2015)
Sodium Butyrate Prevents Memory Impairment by Re-establishing BDNF and GDNF Expression in Experimental Pneumococcal Meningitis
Tatiana Barichello et al.
MOLECULAR NEUROBIOLOGY (2015)
Body Mass Index, Weight Change, and Clinical Progression in Mild Cognitive Impairment and Alzheimer Disease
Lilah M. Besser et al.
ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2014)
Dietary lipids are differentially associated with hippocampal-dependent relational memory in prepubescent children
Carol L. Baym et al.
AMERICAN JOURNAL OF CLINICAL NUTRITION (2014)
Luteolin protects against high fat diet-induced cognitive deficits in obesity mice
Yi Liu et al.
BEHAVIOURAL BRAIN RESEARCH (2014)
Short exposure to a diet rich in both fat and sugar or sugar alone impairs place, but not object recognition memory in rats
Jessica E. Beilharz et al.
BRAIN BEHAVIOR AND IMMUNITY (2014)
High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism
Julia L. Sobesky et al.
BRAIN BEHAVIOR AND IMMUNITY (2014)
Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity
Prabhakara R. Nagareddy et al.
CELL METABOLISM (2014)
Role of cholesterol metabolism in the pathogenesis of Alzheimer's disease
Bernadette Allinquant et al.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2014)
T-Cell Costimulation Protects Obesity-Induced Adipose Inflammation and Insulin Resistance
Jixin Zhong et al.
DIABETES (2014)
Insulin Reverses the High-Fat Diet-Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease
Milene Vandal et al.
DIABETES (2014)
Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation
Margarita Martinez-Medina et al.
GUT (2014)
Liver damage is not reversed during the lean period in diet-induced weight cycling in mice
Sandra Barbosa-da-Silva et al.
HEPATOLOGY RESEARCH (2014)
Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis
Nagendra Singh et al.
IMMUNITY (2014)
Cereal Byproducts Have Prebiotic Potential in Mice Fed a High-Fat Diet
Karin Berger et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)
Short-term high-fat-and-fructose feeding produces insulin signaling alterations accompanied by neurite and synaptic reduction and astroglial activation in the rat hippocampus
Erika Calvo-Ochoa et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2014)
Differential roles of microglia and monocytes in the inflamed central nervous system
Ryo Yamasaki et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2014)
Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring
Silvia S. Kang et al.
JOURNAL OF NEUROINFLAMMATION (2014)
Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury
Jeffrey J. Iliff et al.
JOURNAL OF NEUROSCIENCE (2014)
High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status
Mari Takalo et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2014)
Long-term Impact of Behavioral Weight Loss Intervention on Cognitive Function
Mark A. Espeland et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)
Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer's disease mouse models
Lindsay A. Hohsfield et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2014)
Crosstalk between Adipocytes and Immune Cells in Adipose Tissue Inflammation and Metabolic Dysregulation in Obesity
Jin Young Huh et al.
MOLECULES AND CELLS (2014)
High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology
Elysse M. Knight et al.
NEUROBIOLOGY OF AGING (2014)
Water influx into cerebrospinal fluid is significantly reduced in senile plaque bearing transgenic mice, supporting beta-amyloid clearance hypothesis of Alzheimer's disease
Hironaka Igarashi et al.
NEUROLOGICAL RESEARCH (2014)
Working memory and reward association learning impairments in obesity
Geraldine Coppin et al.
NEUROPSYCHOLOGIA (2014)
Immunohistochemical analysis of tau phosphorylation and astroglial activation with enhanced leptin receptor expression in diet-induced obesity mouse hippocampus
Shunsuke Koga et al.
NEUROSCIENCE LETTERS (2014)
Expression of Aquaporin 4 and Breakdown of the Blood-Brain Barrier after Hypoglycemia-Induced Brain Edema in Rats
Jiangshan Deng et al.
PLOS ONE (2014)
Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia
Ted M. Hsu et al.
FRONTIERS IN AGING NEUROSCIENCE (2014)
Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy
Shuko Takeda et al.
FRONTIERS IN AGING NEUROSCIENCE (2014)
The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's disease
Takahisa Kanekiyo et al.
FRONTIERS IN AGING NEUROSCIENCE (2014)
Arterial Stiffness and β-Amyloid Progression in Nondemented Elderly Adults
Timothy M. Hughes et al.
JAMA NEUROLOGY (2014)
The longer-term impacts of Western diet on human cognition and the brain
Heather Francis et al.
APPETITE (2013)
Increased oxidized low-density lipoprotein causes blood-brain barrier disruption in early-onset preeclampsia through LOX-1
Malou P. H. Schreurs et al.
FASEB JOURNAL (2013)
Habitual fat intake predicts memory function in younger women
E. Leigh Gibson et al.
Frontiers in Human Neuroscience (2013)
Hypercholesterolemia accelerates amyloid β-induced cognitive deficits
Sun Haeng Park et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013)
Diabetes and Hypercholesterolemia Increase Blood-Brain Barrier Permeability and Brain Amyloid Deposition: Beneficial Effects of the LpPLA2 Inhibitor Darapladib
Nimish K. Acharya et al.
JOURNAL OF ALZHEIMERS DISEASE (2013)
Palmitate and Lipopolysaccharide Trigger Synergistic Ceramide Production in Primary Macrophages
Joel D. Schilling et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Involvement of interleukin-1β in the autophagic process of microglia: relevance to Alzheimer's disease
Arnaud Francois et al.
JOURNAL OF NEUROINFLAMMATION (2013)
Gut microbiota and gastrointestinal health: current concepts and future directions
Q. Aziz et al.
NEUROGASTROENTEROLOGY AND MOTILITY (2013)
Is obesity a brain disease?
Gabi Shefer et al.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2013)
Toll-Like Receptor 4 Knockout Mice Are Protected against Endoplasmic Reticulum Stress Induced by a High-Fat Diet
Nicolas Pierre et al.
PLOS ONE (2013)
Sex-Specific Effects of High Fat Diet on Indices of Metabolic Syndrome in 3xTg-AD Mice: Implications for Alzheimer's Disease
Anna M. Barron et al.
PLOS ONE (2013)
Alzheimer's disease and the microbiome
Surjyadipta Bhattacharjee et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2013)
Mechanisms of Obesity-Induced Inflammation and Insulin Resistance: Insights into the Emerging Role of Nutritional Strategies
Maeve A. McArdle et al.
Frontiers in Endocrinology (2013)
Role of the blood-brain barrier in the evolution of feeding and cognition
William A. Banks
BRAIN AND OBESITY (2012)
Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling
Zhen Wang et al.
BRITISH JOURNAL OF NUTRITION (2012)
Characteristics of Aquaporin Expression Surrounding Senile Plaques and Cerebral Amyloid Angiopathy in Alzheimer Disease
Akihiko Hoshi et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2012)
Greater Fructose Consumption Is Associated with Cardiometabolic Risk Markers and Visceral Adiposity in Adolescents
Norman K. Pollock et al.
JOURNAL OF NUTRITION (2012)
Amyloid Precursor Protein and Proinflammatory Changes Are Regulated in Brain and Adipose Tissue in a Murine Model of High Fat Diet-Induced Obesity
Kendra L. Puig et al.
PLOS ONE (2012)
Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver
Neha Sehgal et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes
Laura D. Baker et al.
ARCHIVES OF NEUROLOGY (2011)
Higher Reported Saturated Fat and Refined Sugar Intake Is Associated With Reduced Hippocampal-Dependent Memory and Sensitivity to Interoceptive Signals
Heather M. Francis et al.
BEHAVIORAL NEUROSCIENCE (2011)
Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet Induced Insulin Resistance
Yun Sok Lee et al.
DIABETES (2011)
Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β
Nicolas Dupont et al.
EMBO JOURNAL (2011)
Loss of Astrocyte Polarization in the Tg-ArcSwe Mouse Model of Alzheimer's Disease
Jing Yang et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity
Scott E. Kanoski et al.
PHYSIOLOGY & BEHAVIOR (2011)
Regulation of Inflammation by Short Chain Fatty Acids
Marco A. R. Vinolo et al.
NUTRIENTS (2011)
Adverse associations between visceral adiposity, brain structure, and cognitive performance in healthy elderly
Vivian Isaac et al.
FRONTIERS IN AGING NEUROSCIENCE (2011)
Increased Food Intake Leads to Obesity and Insulin Resistance in the Tg2576 Alzheimer's Disease Mouse Model
Motoyuki Kohjima et al.
ENDOCRINOLOGY (2010)
The Effects of a High-Energy Diet on Hippocampal Function and Blood-Brain Barrier Integrity in the Rat
Scott E. Kanoski et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Cognitive impairment following high fat diet consumption is associated with brain inflammation
Paul J. Pistell et al.
JOURNAL OF NEUROIMMUNOLOGY (2010)
Aquaporin Expression in the Brains of Patients With or Without Cerebral Amyloid Angiopathy
Parham Moftakhar et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2010)
Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits
Celine Ullrich et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2010)
High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model
Carl Julien et al.
NEUROBIOLOGY OF AGING (2010)
Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons
Xuefei Wu et al.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2008)
High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice
L. Thirumangalakudi et al.
JOURNAL OF NEUROCHEMISTRY (2008)
A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans
Kim-Anne Le et al.
AMERICAN JOURNAL OF CLINICAL NUTRITION (2006)
The role of bifidobacteria thermal injury in rats
Zhongtang Wang et al.
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE (2006)
Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease
M Kivipelto et al.
ARCHIVES OF NEUROLOGY (2005)
Palmitate-induced apoptosis in cultured bovine retinal pericytes - Roles of NAD(P)H oxidase, oxidant stress, and ceramide
JM Cacicedo et al.
DIABETES (2005)
Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
L Ho et al.
FASEB JOURNAL (2004)
Obesity is associated with macrophage accumulation in adipose tissue
SP Weisberg et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
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