期刊
AGEING RESEARCH REVIEWS
卷 70, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2021.101414
关键词
Neutrophil gelatinase-associated lipocalin (NGAL); Neurodegenerative disease; Chronic inflammation; Neuroinflammation; Inflammageing; Lifestyle
资金
- Internationale Stichting Alzheimer Onderzoek (ISAO grant) [06511]
- ZonMW Deltaplan Dementie Memorabel [733050815, 733050501]
- Inter-university Poles of Attraction (IAP Network) of the Belgian Federal Science Policy Office [P7/16]
- Methusalem excellence grant of the Flemish Government
- Thomas Riellaerts research fund
- University Research Fund of the University of Antwerp
- Alzheimer Center Groningen
- Research School of Behavioral and Cognitive Neurosciences (BCN)
- Stichting Hadders-De Cock [201730]
- Alzheimer Nederland [WE. 13-2015-19]
- NeuroSearch Antwerp
Chronic inflammation is important in many age-related central nervous system diseases, with Lipocalin 2 being identified as a key constituent in aging and age-related brain diseases.
Chronic (neuro)inflammation plays an important role in many age-related central nervous system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular dementia. Inflammation also characterizes many conditions that form a risk factor for these CNS disorders, such as physical inactivity, obesity and cardiovascular disease. Lipocalin 2 (Lcn2) is an inflammatory protein shown to be involved in different age-related CNS diseases, as well as risk factor conditions thereof. Lcn2 expression is increased in the periphery and the brain in different age-related CNS diseases and also their risk factor conditions. Experimental studies indicate that Lcn2 contributes to various neuropathophysiological processes of age-related CNS diseases, including exacerbated neuroinflammation, cell death and iron dysregulation, which may negatively impact cognitive function. We hypothesize that increased Lcn2 levels as a result of age-related risk factor conditions may sensitize the brain and increase the risk to develop age-related CNS diseases. In this review we first provide a comprehensive overview of the known functions of Lcn2, and its effects in the CNS. Subsequently, this review explores Lcn2 as a potential (neuro)inflammatory link between different risk factor conditions and the development of age-related CNS disorders. Altogether, evidence convincingly indicates Lcn2 as a key constituent in ageing and age-related brain diseases.
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