期刊
ADVANCES IN THERAPY
卷 38, 期 8, 页码 4505-4519出版社
SPRINGER
DOI: 10.1007/s12325-021-01833-4
关键词
COVID-19; Coronavirus; Pulmonary sequelae; Pulmonary function tests; Radiological fibrosis
资金
- National Institute of Health Research, UK
After the first year of the COVID-19 pandemic, over 78 million survivors were recorded. A retrospective analysis on 221 hospitalized COVID survivors found that persistent pulmonary sequelae were associated with smoking history, pre-existing diabetes, and length of stay. Tests showed abnormalities in pulmonary function and evidence of ground glass opacities and fibrosis on CT scans, indicating potential long-term lung issues in a portion of survivors.
Introduction At the end of the first year of the COVID-19 pandemic, more than 78 million known survivors were recorded. The long-term pulmonary sequelae of COVID-19 remain unknown. Methods We performed a retrospective analysis of a post-COVID follow-up service to estimate the burden of persistent pulmonary morbidity in hospitalised COVID survivors. Results A total of 221 patients were followed-up: 44 intensive care unit (ICU) and 177 ward patients. Further investigations were planned as per British Thoracic Society Guidelines: For all ICU patients (n = 44) and for 38 of 177 (21%) ward-based patients who had persistent symptoms and/or persistent radiographic changes on CXR at their initial 8-week follow-up visit. In the ward-based cohort, statistically significant associations with persistent symptoms were being an ex- or current smoker, having pre-existing diabetes, and having a longer length of stay. In patients requiring further investigations, pulmonary function tests (PFTs; n = 67) at an average of 15 weeks post-discharge showed abnormalities in at least one PFT parameter in 79% (equating to 24% of the entire cohort). The most common abnormality was an abnormal diffusion capacity of carbon monoxide (TLCO), highest in the ICU cohort (64% ICU vs. 38% non-ICU). TLCO correlated negatively with length of stay and with maximum inspired FiO(2) in the patient group as a whole. In ICU patients, TLCO correlated negatively with maximum inspired positive airway pressure. Computed tomography scans (n = 72) at an average of 18 weeks post-discharge showed evidence of persistent ground glass opacities in 44% and fibrosis in 21% (equating to 7% of the entire cohort). Conclusion Our data add to the growing evidence that there will be pulmonary sequelae in a proportion of COVID survivors, providing some insight into what may become a significant chronic global health problem.
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