Nanoprecipitation as a simple and straightforward process to create complex polymeric colloidal morphologies

Polymeric nanoparticles are highly important functional nanomaterials for a large range of applications from therapeutics to energy. Advances in nanotechnology have enabled the engineering of multifunctional polymeric nanoparticles with a variety of shapes and inner morphologies. Thanks to its inherent simplicity, the nanoprecipitation technique has progressively become a popular approach to construct polymeric nanoparticles with precise control of nanostructure. The present review highlights the great capability of this technique in controlling the fabrication of various polymeric nanostructures of interest. In particular, we show here how the nanoprecipitation of either block copolymers or mixtures of homopolymers can afford a myriad of colloids displaying equilibrium (typically onion-like) or out-of-equilibrium (stacked lamellae, porous cores) morphologies, depending whether the system freezes while passing the glass transition or crystallization point of starting materials. We also show that core-shell morphologies, either from polymeric or oil/polymer mixtures, are attainable by this one-pot process. A final discussion proposes new directions to enlarge the scope and possible achievements of the process.

Automated summary

Polymeric nanoparticles are important functional nanomaterials with various shapes and inner morphologies, which can be precisely controlled using the nanoprecipitation technique. This technique allows for the fabrication of a wide range of polymeric nanostructures, including equilibrium and out-of-equilibrium morphologies, as well as core-shell structures. New directions are proposed to further expand the scope and potential achievements of this process.