I2-Promoted [3+2] Cyclization of 1,3-Diketones with Potassium Thiocyanate: a Route to Thiazol-2(3H)-One Derivatives

An I-2 -promoted strategy has been developed for the synthesis of thiazol-2(3H)-one derivatives from 1,3-diketones with potassium thiocyanate. This [3 + 2] cyclization reaction involves C-S and C-N bond formation and exhibits good functional group tolerance. A series of thiazol-2(3H)-one derivatives are obtained in moderate to good yields.

Automated summary

A strategy promoted by I-2 has been developed for the synthesis of thiazol-2(3H)-one derivatives, involving C-S and C-N bond formation with good functional group tolerance. A series of thiazol-2(3H)-one derivatives are obtained in moderate to good yields.