Multicomponent Catalytic Enantioselective Synthesis of Isoxazolidin-5-Ones

We report herein a strategy to afford a multicomponent catalytic enantioselective synthesis of beta-substituted isoxazolidin-5-ones via a KMC process promoted by a suited cupreine used as bifunctional organocatalyst. The hydroxamic acid component, with a sterically hindered amide moiety, proved to be key for the successful formation and transformation of the obtained original N-amide isoxazolidin-5-ones.

Automated summary

The strategy reported involves a multicomponent catalytic enantioselective synthesis of beta-substituted isoxazolidin-5-ones via a KMC process promoted by a suitable bifunctional organocatalyst. The hydroxamic acid component with sterically hindered amide moiety is crucial for the successful formation and transformation of the N-amide isoxazolidin-5-ones obtained.