Recent Advances in Cobalt-Catalyzed, Directing-Group-Assisted C-H Bond Amidation Reactions

C-N bond formation reactions have garnered a lot of interest in recent years due to the predominance of nitrogen-containing compounds in most pharmacological medications. Since traditional approaches have several limitations, the transition metal-catalyzed C-H amidation/amination process has arisen as a more atom-friendly option. Because there are so many distinct kinds of C-H bonds in organic molecules, selective amidation of C-H bonds has always been a challenge. In this scenario, the directing-group-assisted C-H amidation has received considerable attention, especially with inexpensive metal cobalt, due to its unique properties and efficiency. We summarize recent developments in cobalt-catalyzed directing-group-aided C-H bond amidation reactions in this review. We briefly discuss the evolution of directing group preferences and their function in the site selection.

Automated summary

C-N bond formation reactions have gained significant interest recently due to the prevalence of nitrogen-containing compounds in pharmaceuticals. The use of directing-group-assisted C-H amidation with cobalt as a catalyst has been a focus for its unique properties and efficiency in selective amidation of C-H bonds. The evolution of directing group preferences and their function in site selection have been discussed in recent developments of this field.