期刊
ADVANCED MATERIALS
卷 33, 期 30, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202008615
关键词
lanthanide-doped nanoparticles; luminescence imaging; photothermal therapy; temperature sensing
类别
资金
- National Natural Science Foundation of China [21527801, 82001945, 61905130]
- Natural Science Foundation of Beijing Municipality [KZ201810028045]
- Beijing Municipal Education Commission Outstanding Young Individual Project [CITTCD201904082]
- Beijing Talent Foundation Outstanding Young Individual Project [2015000026833ZK02]
- Shanghai Pujiang Program [20PJ1410700]
- Capacity Building for Sci-Tech Innovation-Fundamental Scientific Research Funds [19530050179, 025185305000/195]
- Yanjing Young Scholar Program
- Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-year Plan [IDHT20180517]
This study developed GSH-activatable nanocomposites for customized photothermal therapy of subcutaneous orthotopic cancer, evaluating the efficacy of photothermal conversion agents by determining GSH concentration and accumulated agent amount in vivo, allowing personalized treatment for each individual case.
Photothermal therapy (PTT) is a potentially advanced strategy for highly precise cancer treatment. Tumor-microenvironment-activatable agents provide useful tools for PTT, but their photothermal conversion capacities vary and cannot be evaluated in vivo; thus, a general PTT prescription does not work with individual activatable agents. Here, glutathione (GSH)-activatable nanocomposites, silicomolybdate-functionalized NaLuF4:Yb,Er@NaLuF4@NaLuF4:Nd are prepared, for customized PTT of subcutaneous orthotopic cancer. By simultaneously determining intratumoral GSH concentration and the amount of accumulated agent using multiple orthogonal luminescent emissions of nanocomposites, near-infrared absorbance of photothermal conversion agents is evaluated in vivo, based on the optimized irradiating prescriptions (irradiating power density and time) established. This allows customized PTT of each individual case with high efficacy and viability. This work also includes a method for investigating individual intratumoral variation, and the development of the next generation of customized nanomedicine for efficacious PTT of subcutaneous orthotopic cancer.
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