期刊
ADVANCED MATERIALS
卷 33, 期 40, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202008788
关键词
bioelectronics; collagen; piezoelectrics; poly(vinylidene fluoride-co-trifluoroethylene); tendon regeneration
类别
资金
- Science Foundation Ireland [16/BBSRC/3317]
- H2020 Marie Skodowska-Curie Actions [898737]
- Science Foundation Ireland (SFI)
- European Regional Development Fund [13/RC/2073, 13/RC/2073_P2]
- IReL
- Science Foundation Ireland (SFI) [16/BBSRC/3317] Funding Source: Science Foundation Ireland (SFI)
- Marie Curie Actions (MSCA) [898737] Funding Source: Marie Curie Actions (MSCA)
Tendon disease is an unmet clinical need in orthopaedic surgery, and bioelectronic therapies show promise in treating musculoskeletal diseases by activating tissue regeneration-specific signaling pathways. Piezoelectric materials represent a paradigm shift in biomedicine, with self-powered bioelectronic devices accelerating repair processes through motion-powered stimulation.
Tendon disease constitutes an unmet clinical need and remains a critical challenge in the field of orthopaedic surgery. Innovative solutions are required to overcome the limitations of current tendon grafting approaches, and bioelectronic therapies show promise in treating musculoskeletal diseases, accelerating functional recovery through the activation of tissue regeneration-specific signaling pathways. Self-powered bioelectronic devices, particularly piezoelectric materials, represent a paradigm shift in biomedicine, negating the need for battery or external powering and complementing existing mechanotherapy to accelerate the repair processes. Here, the dynamic response of tendon cells to a piezoelectric collagen-analogue scaffold comprised of aligned nanoscale fibers made of the ferroelectric material poly(vinylidene fluoride-co-trifluoroethylene) is shown. It is demonstrated that motion-powered electromechanical stimulation of tendon tissue through piezo-bioelectric device results in ion channel modulation in vitro and regulates specific tissue regeneration signaling pathways. Finally, the potential of the piezo-bioelectronic device in modulating the progression of tendinopathy-associated processes in vivo, using a rat Achilles acute injury model is shown. This study indicates that electromechanical stimulation regulates mechanosensitive ion channel sensitivity and promotes tendon-specific over non-tenogenic tissue repair processes.
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